Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2788713..2789289 Replicon chromosome
Accession NZ_CP051132
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag HDB52_RS13350 Protein ID WP_015572580.1
Coordinates 2788713..2789000 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag HDB52_RS13355 Protein ID WP_017694570.1
Coordinates 2788987..2789289 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS13325 2783831..2784526 + 696 WP_032647138.1 winged helix-turn-helix domain-containing protein -
HDB52_RS13330 2784676..2785146 + 471 WP_032647140.1 MarR family transcriptional regulator -
HDB52_RS13335 2785143..2786210 + 1068 WP_026094404.1 HlyD family secretion protein -
HDB52_RS13340 2786200..2787276 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
HDB52_RS13345 2787273..2788544 - 1272 WP_032647142.1 DUF445 domain-containing protein -
HDB52_RS13350 2788713..2789000 + 288 WP_015572580.1 BrnT family toxin Toxin
HDB52_RS13355 2788987..2789289 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
HDB52_RS13360 2789318..2789956 - 639 WP_032647144.1 LysE family translocator -
HDB52_RS13365 2789995..2790747 - 753 WP_015572582.1 AraC family transcriptional regulator -
HDB52_RS13370 2790901..2792271 + 1371 WP_032647147.1 NAD-dependent succinate-semialdehyde dehydrogenase -
HDB52_RS13375 2792449..2792994 - 546 WP_006810254.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T153563 WP_015572580.1 NZ_CP051132:2788713-2789000 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

>T153563 NZ_CP066968:366082-366216 [Xanthomonas campestris pv. incanae]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT153563 WP_017694570.1 NZ_CP051132:2788987-2789289 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT153563 NZ_CP066968:365853-366005 [Xanthomonas campestris pv. incanae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCTGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References