Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1844721..1845325 Replicon chromosome
Accession NZ_CP051132
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag HDB52_RS08935 Protein ID WP_071788668.1
Coordinates 1845140..1845325 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag HDB52_RS08930 Protein ID WP_023295606.1
Coordinates 1844721..1845125 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS08915 1840261..1841079 - 819 WP_032649828.1 helix-turn-helix domain-containing protein -
HDB52_RS08920 1841305..1842705 + 1401 WP_017693791.1 MFS transporter -
HDB52_RS08925 1842716..1844665 + 1950 WP_032649830.1 glycoside hydrolase family 127 protein -
HDB52_RS08930 1844721..1845125 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HDB52_RS08935 1845140..1845325 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
HDB52_RS08940 1845575..1847113 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
HDB52_RS08945 1847280..1848164 + 885 WP_003860164.1 ROK family protein -
HDB52_RS08950 1848168..1850006 - 1839 WP_017693788.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T153561 WP_071788668.1 NZ_CP051132:c1845325-1845140 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T153561 NZ_CP066968:c21092-20937 [Xanthomonas campestris pv. incanae]
GTGATCCTGCTCGATACCAATGTCATCTTCGGGCCCAATCTGCATGTCGTCGCCTGGATCGATGCGCAGGCCGTTGAAAC
ACTGTTCCTGTCGGTCGTGACGGTGGCCGAATTGCGATCTGGAGACATTCAGGATTTCAGACCCCTGATGAAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT153561 WP_023295606.1 NZ_CP051132:c1845125-1844721 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT153561 NZ_CP066968:c21342-21094 [Xanthomonas campestris pv. incanae]
ATGCCTTCTTTCACCGTCCGCAACATCCCGGAGGATGTGCATCGCGCCATCCGGGCACGTGCTGCCCAACACGGGCGCAG
CACCGAGGCGGAGATCCGCGCGATCCTTGAATCAGCAGCCAGGCCAGCCGACCGGGTCAAACTGGGCGCGTTGCTGGTGG
ACATCGGCCGCGACGCTGGCCTGACGGCAAAGAGGCTGACGCCTTCGCCAAGTTACGCGACACGGCCGCGATCAAGCCGA
TCGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References