Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1138928..1139585 Replicon chromosome
Accession NZ_CP051132
Organism Enterobacter hormaechei strain AMS-38

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag HDB52_RS05500 Protein ID WP_017382887.1
Coordinates 1138928..1139338 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HDB52_RS05505 Protein ID WP_003863437.1
Coordinates 1139319..1139585 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HDB52_RS05480 1134926..1136659 - 1734 WP_032649421.1 single-stranded-DNA-specific exonuclease RecJ -
HDB52_RS05485 1136665..1137378 - 714 WP_015571792.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HDB52_RS05490 1137407..1138303 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HDB52_RS05495 1138405..1138926 + 522 WP_032649423.1 flavodoxin FldB -
HDB52_RS05500 1138928..1139338 - 411 WP_017382887.1 protein YgfX Toxin
HDB52_RS05505 1139319..1139585 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HDB52_RS05510 1139880..1140860 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
HDB52_RS05515 1140972..1141631 - 660 WP_003863433.1 hemolysin III family protein -
HDB52_RS05520 1141898..1142629 + 732 WP_032649427.1 MurR/RpiR family transcriptional regulator -
HDB52_RS05525 1142746..1144179 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T153560 WP_017382887.1 NZ_CP051132:c1139338-1138928 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T153560 NZ_CP066966:c4603230-4603078 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT153560 WP_003863437.1 NZ_CP051132:c1139585-1139319 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT153560 NZ_CP066966:c4603001-4602867 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References