153549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 980887..981523 Replicon chromosome
Accession NZ_CP051128
Organism Priestia megaterium strain S2

Toxin (Protein)


Gene name mazF Uniprot ID K6DRS5
Locus tag HFZ78_RS04850 Protein ID WP_007083556.1
Coordinates 981173..981523 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A6H1NY36
Locus tag HFZ78_RS04845 Protein ID WP_066097189.1
Coordinates 980887..981168 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFZ78_RS04825 976745..977473 - 729 WP_168241575.1 rhomboid family intramembrane serine protease -
HFZ78_RS04830 977578..977928 + 351 WP_168241576.1 holo-ACP synthase -
HFZ78_RS04835 978313..979326 + 1014 WP_168241577.1 outer membrane lipoprotein carrier protein LolA -
HFZ78_RS04840 979452..980615 + 1164 WP_168241578.1 alanine racemase -
HFZ78_RS04845 980887..981168 + 282 WP_066097189.1 CopG family ribbon-helix-helix protein Antitoxin
HFZ78_RS04850 981173..981523 + 351 WP_007083556.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
HFZ78_RS04855 981840..984029 + 2190 WP_210427098.1 helix-hairpin-helix domain-containing protein -
HFZ78_RS04860 984279..984392 - 114 WP_088085061.1 cortex morphogenetic protein CmpA -
HFZ78_RS04865 984488..984961 + 474 WP_168241580.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T153549 WP_007083556.1 NZ_CP051128:981173-981523 [Priestia megaterium]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

>T153549 NZ_CP066959:301079-301231 [Xanthomonas campestris pv. incanae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGATAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10805.41 Da        Isoelectric Point: 8.4664

>AT153549 WP_066097189.1 NZ_CP051128:980887-981168 [Priestia megaterium]
VAESGATTEILVKLPQHLLTELDGFVKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLRIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT153549 NZ_CP066959:301308-301442 [Xanthomonas campestris pv. incanae]
ATGAAGCGTGCAATTGCATTGTTGGTACTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6DRS5

Antitoxin

Source ID Structure
AlphaFold DB A0A6H1NY36

References