Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1859361..1860054 | Replicon | chromosome |
| Accession | NZ_CP051005 | ||
| Organism | Enterococcus faecalis strain TH4125 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | S4BLV4 |
| Locus tag | GRB94_RS09295 | Protein ID | WP_002378467.1 |
| Coordinates | 1859710..1860054 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | GRB94_RS09290 | Protein ID | WP_002364355.1 |
| Coordinates | 1859361..1859693 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GRB94_RS09245 | 1854833..1855567 | - | 735 | WP_002378463.1 | ERF family protein | - |
| GRB94_RS09250 | 1855560..1855877 | - | 318 | WP_002357007.1 | hypothetical protein | - |
| GRB94_RS09255 | 1856097..1856651 | + | 555 | WP_002357006.1 | hypothetical protein | - |
| GRB94_RS09260 | 1856936..1857272 | - | 337 | Protein_1789 | hypothetical protein | - |
| GRB94_RS09265 | 1857309..1857518 | - | 210 | WP_002378465.1 | hypothetical protein | - |
| GRB94_RS09270 | 1857573..1857761 | + | 189 | WP_002357001.1 | YegP family protein | - |
| GRB94_RS09275 | 1857787..1858512 | - | 726 | WP_002378466.1 | phage regulatory protein | - |
| GRB94_RS09280 | 1858551..1858862 | - | 312 | WP_002381719.1 | hypothetical protein | - |
| GRB94_RS09285 | 1858873..1859049 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| GRB94_RS09290 | 1859361..1859693 | + | 333 | WP_002364355.1 | helix-turn-helix domain-containing protein | Antitoxin |
| GRB94_RS09295 | 1859710..1860054 | + | 345 | WP_002378467.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| GRB94_RS09300 | 1860090..1860818 | + | 729 | WP_002378468.1 | potassium channel family protein | - |
| GRB94_RS09305 | 1860918..1862066 | + | 1149 | WP_002378469.1 | site-specific integrase | - |
| GRB94_RS09310 | 1862007..1862537 | - | 531 | WP_002378470.1 | type II secretion system GspH family protein | - |
| GRB94_RS09315 | 1862534..1862809 | - | 276 | WP_002356991.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| GRB94_RS09320 | 1862809..1863855 | - | 1047 | WP_002369171.1 | type II secretion system F family protein | - |
| GRB94_RS09325 | 1863812..1864780 | - | 969 | WP_002364362.1 | Flp pilus assembly complex ATPase component TadA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1823023..1880916 | 57893 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13712.62 Da Isoelectric Point: 5.5523
>T153533 WP_002378467.1 NZ_CP051005:1859710-1860054 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T153533 NZ_CP066949:c1240201-1239710 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT153533 WP_002364355.1 NZ_CP051005:1859361-1859693 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT153533 NZ_CP066949:c1240488-1240198 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACGGATTTCGTGCTGGACGCGGCGCGCTCGGCTGCCGAGGAAGTCTTGC
TGGACCAGACCCTCATCACGGCCAGTCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACAATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA
ATGTCCACACCCAACACTACGCCCGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACGGATTTCGTGCTGGACGCGGCGCGCTCGGCTGCCGAGGAAGTCTTGC
TGGACCAGACCCTCATCACGGCCAGTCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACAATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|