Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3770017..3770848 Replicon chromosome
Accession NZ_CP051001
Organism Escherichia coli O157:H16 str. 98-3133

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag BY40_RS18710 Protein ID WP_000854814.1
Coordinates 3770474..3770848 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID C0ST46
Locus tag BY40_RS18705 Protein ID WP_001285587.1
Coordinates 3770017..3770385 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BY40_RS18670 (3765068) 3765068..3766138 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
BY40_RS18675 (3766274) 3766274..3766951 + 678 WP_001362823.1 hypothetical protein -
BY40_RS18680 (3766967) 3766967..3767377 + 411 WP_000846704.1 hypothetical protein -
BY40_RS18685 (3767598) 3767598..3768419 + 822 WP_001234710.1 DUF932 domain-containing protein -
BY40_RS18690 (3768682) 3768682..3769155 + 474 WP_001373897.1 antirestriction protein -
BY40_RS18695 (3769171) 3769171..3769647 + 477 WP_001186773.1 RadC family protein -
BY40_RS18700 (3769716) 3769716..3769937 + 222 WP_000692323.1 DUF987 domain-containing protein -
BY40_RS18705 (3770017) 3770017..3770385 + 369 WP_001285587.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
BY40_RS18710 (3770474) 3770474..3770848 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
BY40_RS18715 (3770845) 3770845..3771039 + 195 WP_000988601.1 DUF5983 family protein -
BY40_RS18720 (3771085) 3771085..3771165 + 81 Protein_3679 hypothetical protein -
BY40_RS18725 (3771454) 3771454..3771600 - 147 Protein_3680 transposase domain-containing protein -
BY40_RS18730 (3771702) 3771702..3771836 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
BY40_RS18735 (3771937) 3771937..3772266 - 330 WP_000450409.1 DUF496 family protein -
BY40_RS18740 (3772438) 3772438..3773496 - 1059 WP_001200894.1 FUSC family protein -
BY40_RS18745 (3773694) 3773694..3774167 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
BY40_RS18750 (3774286) 3774286..3775452 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T153523 WP_000854814.1 NZ_CP051001:3770474-3770848 [Escherichia coli O157:H16 str. 98-3133]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T153523 NZ_CP066945:c1316911-1316420 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13577.44 Da        Isoelectric Point: 6.3139

>AT153523 WP_001285587.1 NZ_CP051001:3770017-3770385 [Escherichia coli O157:H16 str. 98-3133]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT153523 NZ_CP066945:c1317198-1316908 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure

References