Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3101879..3102517 Replicon chromosome
Accession NZ_CP051001
Organism Escherichia coli O157:H16 str. 98-3133

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag BY40_RS15190 Protein ID WP_000813794.1
Coordinates 3101879..3102055 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BY40_RS15195 Protein ID WP_001270286.1
Coordinates 3102101..3102517 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BY40_RS15170 (3097498) 3097498..3098673 - 1176 WP_001236265.1 BenE family transporter YdcO -
BY40_RS15175 (3098765) 3098765..3099301 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
BY40_RS15180 (3099374) 3099374..3101335 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
BY40_RS15185 (3101427) 3101427..3101657 - 231 WP_000494244.1 YncJ family protein -
BY40_RS15190 (3101879) 3101879..3102055 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
BY40_RS15195 (3102101) 3102101..3102517 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
BY40_RS15200 (3102596) 3102596..3104002 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
BY40_RS15205 (3104247) 3104247..3105392 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
BY40_RS15210 (3105410) 3105410..3106423 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
BY40_RS15215 (3106424) 3106424..3107365 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T153512 WP_000813794.1 NZ_CP051001:3101879-3102055 [Escherichia coli O157:H16 str. 98-3133]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T153512 NZ_CP066936:c4688947-4688795 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT153512 WP_001270286.1 NZ_CP051001:3102101-3102517 [Escherichia coli O157:H16 str. 98-3133]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT153512 NZ_CP066936:c4688718-4688584 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References