153501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 82818..83353 Replicon plasmid pF8704-2_3
Accession NZ_CP051000
Organism Escherichia coli O39:NM str. F8704-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag P411_RS28110 Protein ID WP_001270421.1
Coordinates 83066..83353 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag P411_RS28105 Protein ID WP_001132895.1
Coordinates 82818..83069 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P411_RS28075 77889..78311 - 423 WP_000271766.1 DUF1380 family protein -
P411_RS28080 78358..78621 - 264 Protein_99 antirestriction protein -
P411_RS28085 78637..79753 + 1117 Protein_100 translesion error-prone DNA polymerase V subunit UmuC -
P411_RS28090 79894..80856 - 963 WP_000756323.1 ParB family protein -
P411_RS28095 80853..82058 - 1206 WP_000817645.1 AAA family ATPase -
P411_RS28100 82432..82644 + 213 WP_000402946.1 hypothetical protein -
P411_RS28105 82818..83069 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P411_RS28110 83066..83353 + 288 WP_001270421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P411_RS28115 83358..83630 + 273 Protein_106 DDE-type integrase/transposase/recombinase -
P411_RS28120 83647..84330 - 684 Protein_107 IS3-like element ISEc31 family transposase -
P411_RS28125 84368..85906 - 1539 WP_165899070.1 IS66-like element ISEc22 family transposase -
P411_RS28130 85955..86302 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
P411_RS28135 86299..86679 - 381 WP_001466366.1 transposase -
P411_RS28140 87106..88083 + 978 WP_000361612.1 RepB family plasmid replication initiator protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pet / espT / hlyC / hlyA / hlyB / hlyD 1..91886 91886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11244.27 Da        Isoelectric Point: 10.4703

>T153501 WP_001270421.1 NZ_CP051000:83066-83353 [Escherichia coli O39:NM str. F8704-2]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T153501 NZ_CP066932:c4561069-4560935 [Xanthomonas campestris pv. raphani]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT153501 WP_001132895.1 NZ_CP051000:82818-83069 [Escherichia coli O39:NM str. F8704-2]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT153501 NZ_CP066932:c4561301-4561149 [Xanthomonas campestris pv. raphani]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References