Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4321320..4321945 Replicon chromosome
Accession NZ_CP050998
Organism Escherichia coli O39:NM str. F8704-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P411_RS21690 Protein ID WP_000911330.1
Coordinates 4321547..4321945 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P411_RS21685 Protein ID WP_000450524.1
Coordinates 4321320..4321547 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P411_RS21660 (4317123) 4317123..4317593 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
P411_RS21665 (4317593) 4317593..4318165 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P411_RS21670 (4318311) 4318311..4319189 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P411_RS21675 (4319206) 4319206..4320240 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
P411_RS21680 (4320453) 4320453..4321166 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P411_RS21685 (4321320) 4321320..4321547 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P411_RS21690 (4321547) 4321547..4321945 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P411_RS21695 (4322092) 4322092..4322955 + 864 WP_001267498.1 neutral zinc metallopeptidase -
P411_RS21700 (4322970) 4322970..4324985 + 2016 WP_000829394.1 tRNA cytosine(34) acetyltransferase TmcA -
P411_RS21705 (4325059) 4325059..4325757 + 699 WP_000679812.1 esterase -
P411_RS21710 (4325867) 4325867..4326067 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T153488 WP_000911330.1 NZ_CP050998:4321547-4321945 [Escherichia coli O39:NM str. F8704-2]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T153488 NZ_CP066926:c4522247-4522095 [Xanthomonas campestris pv. incanae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT153488 WP_000450524.1 NZ_CP050998:4321320-4321547 [Escherichia coli O39:NM str. F8704-2]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT153488 NZ_CP066926:c4522018-4521884 [Xanthomonas campestris pv. incanae]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References