Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1760763..1761381 Replicon chromosome
Accession NZ_CP050998
Organism Escherichia coli O39:NM str. F8704-2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P411_RS09335 Protein ID WP_001291435.1
Coordinates 1760763..1760981 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag P411_RS09340 Protein ID WP_032361280.1
Coordinates 1761007..1761381 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P411_RS09300 (1756053) 1756053..1756625 + 573 WP_000779826.1 YbaY family lipoprotein -
P411_RS09305 (1756656) 1756656..1756967 - 312 WP_000409911.1 MGMT family protein -
P411_RS09315 (1757346) 1757346..1757699 + 354 WP_000878140.1 DUF1428 domain-containing protein -
P411_RS09320 (1757741) 1757741..1759291 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P411_RS09325 (1759455) 1759455..1759925 - 471 WP_000136192.1 YlaC family protein -
P411_RS09330 (1760041) 1760041..1760592 - 552 WP_000102564.1 maltose O-acetyltransferase -
P411_RS09335 (1760763) 1760763..1760981 - 219 WP_001291435.1 HHA domain-containing protein Toxin
P411_RS09340 (1761007) 1761007..1761381 - 375 WP_032361280.1 Hha toxicity modulator TomB Antitoxin
P411_RS09345 (1761927) 1761927..1765076 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P411_RS09350 (1765099) 1765099..1766292 - 1194 WP_032361279.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153479 WP_001291435.1 NZ_CP050998:c1760981-1760763 [Escherichia coli O39:NM str. F8704-2]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153479 NZ_CP066923:c1293088-1292597 [Xanthomonas campestris pv. incanae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14617.43 Da        Isoelectric Point: 4.7396

>AT153479 WP_032361280.1 NZ_CP050998:c1761381-1761007 [Escherichia coli O39:NM str. F8704-2]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRYFVNATKENPASLSC

Download         Length: 375 bp

>AT153479 NZ_CP066923:c1293375-1293085 [Xanthomonas campestris pv. incanae]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References