Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 831407..832202 | Replicon | chromosome |
| Accession | NZ_CP050998 | ||
| Organism | Escherichia coli O39:NM str. F8704-2 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | P411_RS04720 | Protein ID | WP_000854914.1 |
| Coordinates | 831407..831781 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7U9LM11 |
| Locus tag | P411_RS04725 | Protein ID | WP_001280953.1 |
| Coordinates | 831828..832202 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P411_RS04680 (826411) | 826411..826902 | - | 492 | WP_001297187.1 | DUF1097 domain-containing protein | - |
| P411_RS04685 (827004) | 827004..827558 | - | 555 | WP_001001902.1 | molecular chaperone YcdY | - |
| P411_RS04690 (827582) | 827582..828319 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| P411_RS04695 (828374) | 828374..829312 | - | 939 | WP_000351317.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| P411_RS04705 (829783) | 829783..830625 | - | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
| P411_RS04710 (830710) | 830710..830907 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| P411_RS04715 (830919) | 830919..831410 | - | 492 | WP_000976857.1 | DUF5983 family protein | - |
| P411_RS04720 (831407) | 831407..831781 | - | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| P411_RS04725 (831828) | 831828..832202 | - | 375 | WP_001280953.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| P411_RS04730 (832365) | 832365..832586 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| P411_RS04735 (832649) | 832649..833125 | - | 477 | WP_001186738.1 | RadC family protein | - |
| P411_RS04740 (833141) | 833141..833626 | - | 486 | WP_000214398.1 | antirestriction protein | - |
| P411_RS04745 (833717) | 833717..834535 | - | 819 | WP_001234682.1 | DUF932 domain-containing protein | - |
| P411_RS04750 (834875) | 834875..835945 | - | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| P411_RS04755 (835942) | 835942..836847 | - | 906 | WP_000203541.1 | diguanylate cyclase regulator RdcB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | csgC / csgA / csgB / csgD / csgE / csgF / csgG | 821905..833626 | 11721 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T153476 WP_000854914.1 NZ_CP050998:c831781-831407 [Escherichia coli O39:NM str. F8704-2]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T153476 NZ_CP066921:c4608510-4608358 [Xanthomonas campestris pv. raphani]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13734.56 Da Isoelectric Point: 6.6249
>AT153476 WP_001280953.1 NZ_CP050998:c832202-831828 [Escherichia coli O39:NM str. F8704-2]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS
Download Length: 375 bp
>AT153476 NZ_CP066921:c4608278-4608144 [Xanthomonas campestris pv. raphani]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LXR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LM11 |