Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 5607714..5608236 Replicon chromosome
Accession NZ_CP050975
Organism Streptomyces sp. RPA4-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HEP85_RS24835 Protein ID WP_168529858.1
Coordinates 5607714..5607977 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HEP85_RS24840 Protein ID WP_168529859.1
Coordinates 5607970..5608236 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP85_RS24805 5603425..5603577 + 153 WP_168529853.1 hypothetical protein -
HEP85_RS24810 5603654..5604229 + 576 WP_168529854.1 hypothetical protein -
HEP85_RS24815 5604406..5604801 + 396 WP_168529855.1 hypothetical protein -
HEP85_RS24820 5604915..5606387 + 1473 WP_168529856.1 DHA2 family efflux MFS transporter permease subunit -
HEP85_RS24825 5606584..5607249 + 666 WP_168529857.1 RNA polymerase sigma factor -
HEP85_RS24830 5607285..5607539 + 255 WP_211118053.1 hypothetical protein -
HEP85_RS24835 5607714..5607977 - 264 WP_168529858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEP85_RS24840 5607970..5608236 - 267 WP_168529859.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HEP85_RS24845 5608740..5609402 + 663 WP_168529860.1 RNA polymerase sigma factor -
HEP85_RS24850 5609402..5610477 + 1076 Protein_4857 hypothetical protein -
HEP85_RS24855 5610778..5611632 - 855 WP_211118054.1 L,D-transpeptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-59)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9930.31 Da        Isoelectric Point: 8.5814

>T153470 WP_168529858.1 NZ_CP050975:c5607977-5607714 [Streptomyces sp. RPA4-2]
VSEYRTVFRPEAQAELRKVPRDTALRILAKLTELESDPLGFSTTALVSQPGRRRLRVGDHRVIYTIDDGELVVWVVHVGH
RSTVYET

Download         Length: 264 bp

>T153470 NZ_CP066917:c2407-2093 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10231.63 Da        Isoelectric Point: 4.9372

>AT153470 WP_168529859.1 NZ_CP050975:c5608236-5607970 [Streptomyces sp. RPA4-2]
MTQMPIESIRDVRAHLAEVVERADRDDQPTVITRRGKEVAAVVSIDVLRKYQQWEEREINRIIDERMANRSAGVPIEDIM
KETLARSE

Download         Length: 267 bp

>AT153470 NZ_CP066917:c2673-2395 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References