Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 689920..690485 Replicon plasmid unnamed
Accession NZ_CP050953
Organism Rhodococcus sp. DMU1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HFP48_RS31130 Protein ID WP_168581107.1
Coordinates 690129..690485 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A6H1CA67
Locus tag HFP48_RS31125 Protein ID WP_044476021.1
Coordinates 689920..690132 (+) Length 71 a.a.

Genomic Context

HFP48_RS31120HFP48_RS31125HFP48_RS31130HFP48_RS31135HFP48_RS31140HFP48_RS31145HFP48_RS31105HFP48_RS31110HFP48_RS31115
Location: 688702..689478 (777 bp)
Type: Others
Protein ID: WP_168581106.1
Location: 689920..690132 (213 bp)
Type: Antitoxin
Protein ID: WP_044476021.1
Location: 690129..690485 (357 bp)
Type: Toxin
Protein ID: WP_168581107.1
Location: 691311..693569 (2259 bp)
Type: Others
Protein ID: WP_168581108.1
Location: 693706..694950 (1245 bp)
Type: Others
Protein ID: Protein_621
Location: 695274..695417 (144 bp)
Type: Others
Protein ID: WP_168581109.1
Location: 685464..685715 (252 bp)
Type: Others
Protein ID: Protein_614
Location: 685809..687362 (1554 bp)
Type: Others
Protein ID: WP_168581186.1
Location: 687451..688465 (1015 bp)
Type: Others
Protein ID: Protein_616
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HFP48_RS31105685464..685715-252Protein_614transposase-
HFP48_RS31110685809..687362-1554WP_168581186.1transposase-
HFP48_RS31115687451..688465-1015Protein_616IS256 family transposase-
HFP48_RS31120688702..689478+777WP_168581106.1VOC family protein-
HFP48_RS31125689920..690132+213WP_044476021.1ribbon-helix-helix domain-containing proteinAntitoxin
HFP48_RS31130690129..690485+357WP_168581107.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HFP48_RS31135691311..693569+2259WP_168581108.1NADP-dependent isocitrate dehydrogenase-
HFP48_RS31140693706..694950+1245Protein_621AAA family ATPase-
HFP48_RS31145695274..695417+144WP_168581109.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..716018716018
-flankIS/Tn--685464..685694230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12864.57 Da        Isoelectric Point: 8.9802

>T153468 WP_168581107.1 NZ_CP050953:690129-690485 [Rhodococcus sp. DMU1]
MIRRGHVHWVDLDPAQGSEAAKRRPAVVVSNDRANATAERLGRGVVTVVPLTSNTAHVFAFQVLVEPDESGMPRESKAQA
EQVRSVSVRRLDGDPVGKLSTRTLAALDDALRLHLDLH

Download         Length: 357 bp

>T153468 NZ_CP066916:c6111-5695 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7602.32 Da        Isoelectric Point: 4.0174

>AT153468 WP_044476021.1 NZ_CP050953:689920-690132 [Rhodococcus sp. DMU1]
MTTRFTISLPDEDARVLDEYVRDHGLGGRSAGIRAALRMLGEVGLERDYAAAFVEGGVEDDWDVTSADGE

Download         Length: 213 bp

>AT153468 NZ_CP066916:c6338-6108 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6H1CA67

References