Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 1160..41311 | Replicon | plasmid p1 |
| Accession | NZ_CP050931 | ||
| Organism | Neisseria gonorrhoeae strain NG211 | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | - |
| Locus tag | GHB95_RS11655 | Protein ID | WP_033911112.1 |
| Coordinates | 41311..1160 (+) | Length | -13383.333333333 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | GHB95_RS11660 | Protein ID | WP_003701903.1 |
| Coordinates | 1175..1606 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GHB95_RS11660 (GHB95_11595) | 1175..1606 | + | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| GHB95_RS11665 (GHB95_11600) | 1658..2212 | + | 555 | WP_003701901.1 | recombinase family protein | - |
| GHB95_RS11670 (GHB95_11605) | 2322..2612 | - | 291 | WP_003701899.1 | virulence factor | - |
| GHB95_RS11675 (GHB95_11610) | 2715..3314 | - | 600 | WP_003701898.1 | TrbN protein | - |
| GHB95_RS11680 (GHB95_11615) | 3314..3886 | - | 573 | WP_226888038.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| GHB95_RS11685 (GHB95_11620) | 3879..5486 | - | 1608 | WP_226888039.1 | P-type conjugative transfer protein TrbL | - |
| GHB95_RS11690 (GHB95_11625) | 5721..6497 | - | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
| GHB95_RS11695 (GHB95_11630) | 6510..7949 | - | 1440 | WP_033910174.1 | TrbI/VirB10 family protein | - |
| GHB95_RS11700 (GHB95_11635) | 7953..8363 | - | 411 | WP_003701887.1 | TrbH protein | - |
| GHB95_RS11705 (GHB95_11640) | 8360..9226 | - | 867 | WP_003701885.1 | P-type conjugative transfer protein TrbG | - |
| GHB95_RS11710 (GHB95_11645) | 9239..9946 | - | 708 | WP_033910171.1 | VirB8/TrbF family protein | - |
| GHB95_RS11715 (GHB95_11650) | 9946..12510 | - | 2565 | WP_003701881.1 | VirB4 family type IV secretion/conjugal transfer ATPase | - |
| GHB95_RS11720 (GHB95_11655) | 12507..12824 | - | 318 | WP_013085581.1 | conjugal transfer protein TrbD | - |
| GHB95_RS11725 (GHB95_11660) | 12829..13212 | - | 384 | WP_003701877.1 | conjugal transfer system pilin TrbC | - |
| GHB95_RS11730 (GHB95_11665) | 13314..14312 | - | 999 | WP_003701874.1 | P-type conjugative transfer ATPase TrbB | - |
| GHB95_RS11735 (GHB95_11670) | 14440..14805 | - | 366 | WP_003701872.1 | transcriptional regulator | - |
| GHB95_RS11740 (GHB95_11675) | 14865..15248 | + | 384 | WP_003701870.1 | single-stranded DNA-binding protein | - |
| GHB95_RS11745 (GHB95_11680) | 15252..16130 | + | 879 | WP_003701868.1 | plasmid replication initiator TrfA | - |
| GHB95_RS11750 (GHB95_11685) | 16748..17095 | + | 348 | WP_003701866.1 | hypothetical protein | - |
| GHB95_RS11755 (GHB95_11690) | 17176..17421 | + | 246 | WP_003701863.1 | hypothetical protein | - |
| GHB95_RS11760 (GHB95_11695) | 17431..18186 | + | 756 | WP_003701861.1 | ParA family protein | - |
| GHB95_RS11765 (GHB95_11700) | 18192..19109 | + | 918 | WP_003701858.1 | ParB/RepB/Spo0J family partition protein | - |
| GHB95_RS11770 (GHB95_11705) | 19316..19672 | + | 357 | WP_003701856.1 | hypothetical protein | - |
| GHB95_RS11775 (GHB95_11710) | 19709..20245 | + | 537 | WP_003701854.1 | hypothetical protein | - |
| GHB95_RS11780 (GHB95_11715) | 20302..20784 | - | 483 | WP_003701852.1 | hypothetical protein | - |
| GHB95_RS11785 (GHB95_11720) | 20792..21517 | - | 726 | WP_164823309.1 | conjugal transfer protein TraL | - |
| GHB95_RS11790 | 21518..22219 | - | 702 | WP_226888040.1 | TraK family protein | - |
| GHB95_RS11795 (GHB95_11730) | 22269..22646 | + | 378 | WP_003701845.1 | conjugal transfer protein TraJ | - |
| GHB95_RS11800 (GHB95_11735) | 22649..25042 | + | 2394 | WP_033910166.1 | relaxase/mobilization nuclease domain-containing protein | - |
| GHB95_RS11805 (GHB95_11740) | 25059..26948 | + | 1890 | WP_003701841.1 | type IV secretory system conjugative DNA transfer family protein | - |
| GHB95_RS11810 (GHB95_11745) | 26945..27481 | + | 537 | WP_003701840.1 | conjugative transfer signal peptidase TraF | - |
| GHB95_RS11815 (GHB95_11750) | 27484..29679 | + | 2196 | WP_013085583.1 | DNA topoisomerase 3 | - |
| GHB95_RS11820 (GHB95_11755) | 29701..29865 | + | 165 | WP_003701838.1 | hypothetical protein | - |
| GHB95_RS11825 (GHB95_11760) | 29868..32867 | + | 3000 | WP_014580052.1 | DUF5710 domain-containing protein | - |
| GHB95_RS11830 (GHB95_11765) | 32900..33370 | + | 471 | WP_228547154.1 | transcription elongation factor | - |
| GHB95_RS11835 | 33367..33419 | + | 53 | Protein_36 | twin-arginine translocation signal domain-containing protein | - |
| GHB95_RS11840 (GHB95_11770) | 33493..33927 | + | 435 | WP_229505493.1 | DUF882 domain-containing protein | - |
| GHB95_RS11845 (GHB95_11775) | 33924..34283 | + | 360 | WP_003701922.1 | hypothetical protein | - |
| GHB95_RS11850 (GHB95_11780) | 34650..34964 | + | 315 | WP_082295984.1 | hypothetical protein | - |
| GHB95_RS11855 (GHB95_11785) | 34978..35319 | + | 342 | WP_013085576.1 | hypothetical protein | - |
| GHB95_RS11860 (GHB95_11790) | 35323..36219 | + | 897 | WP_003701917.1 | hypothetical protein | - |
| GHB95_RS11865 (GHB95_11795) | 36371..36844 | - | 474 | WP_013085577.1 | hypothetical protein | - |
| GHB95_RS11870 (GHB95_11800) | 36936..38855 | - | 1920 | WP_025456273.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| GHB95_RS11875 (GHB95_11805) | 38871..38987 | - | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
| GHB95_RS11880 (GHB95_11810) | 39632..39880 | + | 249 | WP_014580056.1 | hypothetical protein | - |
| GHB95_RS11885 (GHB95_11815) | 39877..41085 | + | 1209 | WP_014580057.1 | zeta toxin family protein | - |
| GHB95_RS11890 (GHB95_11820) | 41119..41304 | + | 186 | WP_014580058.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) | - | 1..41356 | 41356 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: -13383.333333333 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T153457 WP_033911112.1 NZ_CP050931:41311-1160 [Neisseria gonorrhoeae]
Download Length: -40150 bp
>T153457 NZ_CP066915:399679-400122 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT153457 WP_003701903.1 NZ_CP050931:1175-1606 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
>AT153457 NZ_CP066915:399452-399682 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|