Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1654949..1655634 | Replicon | chromosome |
| Accession | NZ_CP050930 | ||
| Organism | Neisseria gonorrhoeae strain NG211 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | GHB95_RS08585 | Protein ID | WP_003689143.1 |
| Coordinates | 1655452..1655634 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | GHB95_RS08580 | Protein ID | WP_003691454.1 |
| Coordinates | 1654949..1655350 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GHB95_RS08525 (GHB95_08450) | 1649996..1650211 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| GHB95_RS08530 (GHB95_08455) | 1650263..1650754 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| GHB95_RS08535 (GHB95_08460) | 1650751..1650933 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| GHB95_RS08540 (GHB95_08465) | 1651073..1651759 | - | 687 | WP_082278088.1 | hypothetical protein | - |
| GHB95_RS08545 (GHB95_08470) | 1651828..1651989 | - | 162 | WP_003693867.1 | hypothetical protein | - |
| GHB95_RS08550 (GHB95_08475) | 1651986..1652261 | - | 276 | WP_047918704.1 | hypothetical protein | - |
| GHB95_RS08555 (GHB95_08480) | 1652414..1652746 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| GHB95_RS08560 (GHB95_08485) | 1652887..1653174 | - | 288 | WP_050157611.1 | hypothetical protein | - |
| GHB95_RS08565 (GHB95_08490) | 1653171..1653647 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| GHB95_RS08570 (GHB95_08495) | 1653680..1653880 | - | 201 | WP_003692842.1 | hypothetical protein | - |
| GHB95_RS08575 (GHB95_08500) | 1654090..1654851 | + | 762 | WP_012503753.1 | hypothetical protein | - |
| GHB95_RS08580 (GHB95_08505) | 1654949..1655350 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| GHB95_RS08585 (GHB95_08510) | 1655452..1655634 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| GHB95_RS08590 (GHB95_08515) | 1655804..1656622 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| GHB95_RS08595 (GHB95_08520) | 1656619..1657317 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| GHB95_RS08600 (GHB95_08525) | 1657556..1658266 | - | 711 | WP_025455899.1 | helix-turn-helix transcriptional regulator | - |
| GHB95_RS08605 (GHB95_08530) | 1658382..1658570 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| GHB95_RS08610 (GHB95_08535) | 1658650..1658805 | + | 156 | WP_003689578.1 | hypothetical protein | - |
| GHB95_RS08615 (GHB95_08540) | 1658782..1658970 | - | 189 | WP_050157615.1 | hypothetical protein | - |
| GHB95_RS08620 (GHB95_08545) | 1659143..1659370 | + | 228 | WP_003693879.1 | helix-turn-helix domain-containing protein | - |
| GHB95_RS08625 | 1660049..1660552 | + | 504 | WP_010360005.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1639767..1674028 | 34261 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T153456 WP_003689143.1 NZ_CP050930:c1655634-1655452 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T153456 NZ_CP066915:355289-355636 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT153456 WP_003691454.1 NZ_CP050930:c1655350-1654949 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT153456 NZ_CP066915:355636-355935 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|