Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 675918..676573 Replicon chromosome
Accession NZ_CP050930
Organism Neisseria gonorrhoeae strain NG211

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag GHB95_RS03615 Protein ID WP_003691083.1
Coordinates 676154..676573 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag GHB95_RS03610 Protein ID WP_003688410.1
Coordinates 675918..676154 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHB95_RS03580 (GHB95_03590) 671052..671339 + 288 WP_003688407.1 hypothetical protein -
GHB95_RS03585 (GHB95_03595) 671411..672577 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
GHB95_RS03590 (GHB95_03600) 672588..673478 + 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
GHB95_RS03595 (GHB95_03605) 673861..674247 - 387 Protein_705 IS110 family transposase -
GHB95_RS03600 (GHB95_03610) 674486..674887 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
GHB95_RS03605 (GHB95_03615) 674892..675470 + 579 WP_003688041.1 IS3 family transposase -
GHB95_RS03610 (GHB95_03625) 675918..676154 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
GHB95_RS03615 (GHB95_03630) 676154..676573 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
GHB95_RS03620 (GHB95_03635) 676722..678176 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
GHB95_RS03625 (GHB95_03640) 678173..678874 - 702 WP_003688414.1 lactate utilization protein C -
GHB95_RS03630 (GHB95_03645) 678871..679650 - 780 WP_003701284.1 (Fe-S)-binding protein -
GHB95_RS03635 (GHB95_03650) 679798..681339 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T153455 WP_003691083.1 NZ_CP050930:676154-676573 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T153455 NZ_CP066915:329318-329686 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT153455 WP_003688410.1 NZ_CP050930:675918-676154 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT153455 NZ_CP066915:329100-329321 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References