153445

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1206636..1207287 Replicon chromosome
Accession NZ_CP050911
Organism Acinetobacter baumannii strain DT-Ab020

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag HFD81_RS05715 Protein ID WP_000838146.1
Coordinates 1206636..1206818 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag HFD81_RS05720 Protein ID WP_000966689.1
Coordinates 1206883..1207287 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFD81_RS05670 1201893..1202558 + 666 WP_033841768.1 stress-responsive nuclear envelope protein -
HFD81_RS05675 1202563..1202952 + 390 WP_000008496.1 hypothetical protein -
HFD81_RS05680 1202909..1203322 + 414 WP_001197735.1 hypothetical protein -
HFD81_RS05685 1203331..1203735 + 405 WP_000248324.1 hypothetical protein -
HFD81_RS05690 1203707..1204075 + 369 WP_000539752.1 hypothetical protein -
HFD81_RS05695 1204077..1204475 + 399 WP_001132270.1 hypothetical protein -
HFD81_RS05700 1204477..1204689 + 213 WP_000121166.1 hypothetical protein -
HFD81_RS05705 1204797..1205726 + 930 WP_000094300.1 hypothetical protein -
HFD81_RS05710 1205771..1206304 + 534 WP_001185622.1 hypothetical protein -
HFD81_RS05715 1206636..1206818 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
HFD81_RS05720 1206883..1207287 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HFD81_RS05725 1207368..1207769 + 402 WP_000720591.1 hypothetical protein -
HFD81_RS05730 1207830..1211795 + 3966 WP_000191304.1 tape measure protein -
HFD81_RS05735 1211913..1212254 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1178775..1230180 51405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T153445 WP_000838146.1 NZ_CP050911:1206636-1206818 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T153445 NZ_CP066910:c4805681-4805397 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT153445 WP_000966689.1 NZ_CP050911:1206883-1207287 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT153445 NZ_CP066910:c4805913-4805671 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References