Detailed information of TA system TA153441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1206609..1207260
• Replicon: chromosome
• Accession: NZ_CP050907
• Organism: Acinetobacter baumannii strain DT-Ab022

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HFD80_RS05720
• Protein ID: WP_000838146.1
• Coordinates: 1206609..1206791 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: HFD80_RS05725
• Protein ID: WP_000966689.1
• Coordinates: 1206856..1207260 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFD80_RS05675	1201866..1202531	+	666	WP_033841768.1	stress-responsive nuclear envelope protein	-
HFD80_RS05680	1202536..1202925	+	390	WP_000008496.1	hypothetical protein	-
HFD80_RS05685	1202882..1203295	+	414	WP_001197735.1	hypothetical protein	-
HFD80_RS05690	1203304..1203708	+	405	WP_000248324.1	hypothetical protein	-
HFD80_RS05695	1203680..1204048	+	369	WP_000539752.1	hypothetical protein	-
HFD80_RS05700	1204050..1204448	+	399	WP_001132270.1	hypothetical protein	-
HFD80_RS05705	1204450..1204662	+	213	WP_000121166.1	hypothetical protein	-
HFD80_RS05710	1204770..1205699	+	930	WP_000094300.1	hypothetical protein	-
HFD80_RS05715	1205744..1206277	+	534	WP_001185622.1	hypothetical protein	-
HFD80_RS05720	1206609..1206791	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HFD80_RS05725	1206856..1207260	+	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HFD80_RS05730	1207341..1207742	+	402	WP_000720591.1	hypothetical protein	-
HFD80_RS05735	1207803..1211768	+	3966	WP_000191304.1	tape measure protein	-
HFD80_RS05740	1211886..1212227	+	342	WP_001281459.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1178748..1230153	51405

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T153441 WP_000838146.1 NZ_CP050907:1206609-1206791 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T153441 NZ_CP066910:2033430-2033532 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT153441 WP_000966689.1 NZ_CP050907:1206856-1207260 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT153441 NZ_CP066910:c2033539-2033394 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8