Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1207793..1208444 Replicon chromosome
Accession NZ_CP050904
Organism Acinetobacter baumannii strain DT-Ab057

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag HFD79_RS05730 Protein ID WP_000838146.1
Coordinates 1207793..1207975 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag HFD79_RS05735 Protein ID WP_000966689.1
Coordinates 1208040..1208444 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFD79_RS05685 1203050..1203715 + 666 WP_033841768.1 stress-responsive nuclear envelope protein -
HFD79_RS05690 1203720..1204109 + 390 WP_000008496.1 hypothetical protein -
HFD79_RS05695 1204066..1204479 + 414 WP_001197735.1 hypothetical protein -
HFD79_RS05700 1204488..1204892 + 405 WP_000248324.1 hypothetical protein -
HFD79_RS05705 1204864..1205232 + 369 WP_000539752.1 hypothetical protein -
HFD79_RS05710 1205234..1205632 + 399 WP_001132270.1 hypothetical protein -
HFD79_RS05715 1205634..1205846 + 213 WP_000121166.1 hypothetical protein -
HFD79_RS05720 1205954..1206883 + 930 WP_000094300.1 hypothetical protein -
HFD79_RS05725 1206928..1207461 + 534 WP_001185622.1 hypothetical protein -
HFD79_RS05730 1207793..1207975 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
HFD79_RS05735 1208040..1208444 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HFD79_RS05740 1208525..1208926 + 402 WP_000720591.1 hypothetical protein -
HFD79_RS05745 1208987..1212952 + 3966 WP_000191304.1 tape measure protein -
HFD79_RS05750 1213070..1213411 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1180619..1231337 50718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T153438 WP_000838146.1 NZ_CP050904:1207793-1207975 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T153438 NZ_CP066910:353633-353980 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT153438 WP_000966689.1 NZ_CP050904:1208040-1208444 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT153438 NZ_CP066910:353980-354279 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References