Detailed information of TA system TA153438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1207793..1208444
• Replicon: chromosome
• Accession: NZ_CP050904
• Organism: Acinetobacter baumannii strain DT-Ab057

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HFD79_RS05730
• Protein ID: WP_000838146.1
• Coordinates: 1207793..1207975 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0J1AAF8
• Locus tag: HFD79_RS05735
• Protein ID: WP_000966689.1
• Coordinates: 1208040..1208444 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFD79_RS05685	1203050..1203715	+	666	WP_033841768.1	stress-responsive nuclear envelope protein	-
HFD79_RS05690	1203720..1204109	+	390	WP_000008496.1	hypothetical protein	-
HFD79_RS05695	1204066..1204479	+	414	WP_001197735.1	hypothetical protein	-
HFD79_RS05700	1204488..1204892	+	405	WP_000248324.1	hypothetical protein	-
HFD79_RS05705	1204864..1205232	+	369	WP_000539752.1	hypothetical protein	-
HFD79_RS05710	1205234..1205632	+	399	WP_001132270.1	hypothetical protein	-
HFD79_RS05715	1205634..1205846	+	213	WP_000121166.1	hypothetical protein	-
HFD79_RS05720	1205954..1206883	+	930	WP_000094300.1	hypothetical protein	-
HFD79_RS05725	1206928..1207461	+	534	WP_001185622.1	hypothetical protein	-
HFD79_RS05730	1207793..1207975	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HFD79_RS05735	1208040..1208444	+	405	WP_000966689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HFD79_RS05740	1208525..1208926	+	402	WP_000720591.1	hypothetical protein	-
HFD79_RS05745	1208987..1212952	+	3966	WP_000191304.1	tape measure protein	-
HFD79_RS05750	1213070..1213411	+	342	WP_001281459.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1180619..1231337	50718

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T153438 WP_000838146.1 NZ_CP050904:1207793-1207975 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T153438 NZ_CP066910:353633-353980 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14769.78 Da
• Isoelectric Point: 4.5000

>AT153438 WP_000966689.1 NZ_CP050904:1208040-1208444 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT153438 NZ_CP066910:353980-354279 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A0J1AAF8