Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 904360..905008 Replicon chromosome
Accession NZ_CP050869
Organism Saccharolobus solfataricus strain POZ149

Toxin (Protein)


Gene name vapC Uniprot ID Q97WZ2
Locus tag HFC64_RS04740 Protein ID WP_009991912.1
Coordinates 904360..904746 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97WZ1
Locus tag HFC64_RS04745 Protein ID WP_009991915.1
Coordinates 904733..905008 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFC64_RS04720 (HFC64_04675) 900306..901310 - 1005 WP_009989083.1 endoglucanase -
HFC64_RS04725 (HFC64_04685) 901615..902565 - 951 WP_252973062.1 IS110 family transposase -
HFC64_RS04730 (HFC64_04690) 902724..903008 + 285 Protein_956 IS607-like element ISC1913 family transposase -
HFC64_RS04735 (HFC64_04695) 902992..904212 + 1221 WP_014511730.1 IS200/IS605 family accessory protein TnpB-related protein -
HFC64_RS04740 (HFC64_04700) 904360..904746 - 387 WP_009991912.1 type II toxin-antitoxin system VapC family toxin Toxin
HFC64_RS04745 (HFC64_04705) 904733..905008 - 276 WP_009991915.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HFC64_RS04750 (HFC64_04710) 905379..905615 + 237 WP_009991916.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HFC64_RS04755 (HFC64_04715) 905593..905991 + 399 WP_009991918.1 type II toxin-antitoxin system VapC family toxin -
HFC64_RS04760 (HFC64_04720) 906380..906604 + 225 WP_009991920.1 type II toxin-antitoxin system CcdA family antitoxin -
HFC64_RS04765 (HFC64_04725) 906594..906986 + 393 WP_009991922.1 type II toxin-antitoxin system VapC family toxin -
HFC64_RS04770 (HFC64_04730) 907160..908105 + 946 Protein_964 IS110 family transposase -
HFC64_RS04775 (HFC64_04735) 908209..909357 - 1149 WP_010923706.1 RNA-guided endonuclease TnpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 886494..913879 27385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15042.69 Da        Isoelectric Point: 4.9844

>T153434 WP_009991912.1 NZ_CP050869:c904746-904360 [Saccharolobus solfataricus]
MIFLDANFLIYLNSGVSEVKEYYIKLLTYESLFSDPLVIDEVIYVSKKKYGVKYCDTIEFLDEIVLKYLTVLPITIKEYE
RAKEIMRKYSVKPSDAFHIAVMLNNSINVILSEDKELDKVAEIKRIWI

Download         Length: 387 bp

>T153434 NZ_CP066906:c45909-45760 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10372.22 Da        Isoelectric Point: 7.0185

>AT153434 WP_009991915.1 NZ_CP050869:c905008-904733 [Saccharolobus solfataricus]
MSLTLRVEVGKKGYIIIPKSVRDLVGIKEGDILILTVVGDKIILEPERKVNIREVVKKLEEHERKISYAKRASLGELENI
SLEEELKIDFS

Download         Length: 276 bp

>AT153434 NZ_CP066906:45954-46013 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3KDP7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3MDU1

References