Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 708577..709556 Replicon chromosome
Accession NZ_CP050869
Organism Saccharolobus solfataricus strain POZ149

Toxin (Protein)


Gene name vapC Uniprot ID Q97X87
Locus tag HFC64_RS03615 Protein ID WP_009988462.1
Coordinates 708577..709191 (-) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q97X88
Locus tag HFC64_RS03620 Protein ID WP_009988464.1
Coordinates 709209..709556 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFC64_RS03585 (HFC64_03545) 704593..705192 - 600 WP_009991466.1 DUF2249 domain-containing protein -
HFC64_RS03590 (HFC64_03550) 705919..706161 + 243 WP_009988456.1 hypothetical protein -
HFC64_RS03595 (HFC64_03555) 706142..706486 - 345 WP_009988458.1 hypothetical protein -
HFC64_RS03600 (HFC64_03560) 706490..707254 - 765 WP_009988459.1 plastocyanin/azurin family copper-binding protein -
HFC64_RS03605 (HFC64_03565) 707360..707890 - 531 WP_009988460.1 hemerythrin domain-containing protein -
HFC64_RS03610 (HFC64_03570) 708012..708287 + 276 WP_009988461.1 hypothetical protein -
HFC64_RS03615 (HFC64_03575) 708577..709191 - 615 WP_009988462.1 helix-turn-helix domain-containing protein Toxin
HFC64_RS03620 (HFC64_03580) 709209..709556 - 348 WP_009988464.1 DUF488 domain-containing protein Antitoxin
HFC64_RS03625 (HFC64_03585) 709626..709856 - 231 WP_009988466.1 C2H2-type zinc finger protein -
HFC64_RS03630 (HFC64_03590) 709949..710338 + 390 WP_009988467.1 metal-sulfur cluster assembly factor -
HFC64_RS03635 (HFC64_03595) 710331..710762 - 432 WP_009988468.1 universal stress protein -
HFC64_RS03640 (HFC64_03600) 711188..712120 - 933 WP_009988516.1 dipeptidase -
HFC64_RS03645 (HFC64_03605) 712065..713261 - 1197 WP_009988517.1 MFS transporter -
HFC64_RS03650 (HFC64_03610) 713298..714140 - 843 WP_009988518.1 KaiC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23424.52 Da        Isoelectric Point: 8.6438

>T153433 WP_009988462.1 NZ_CP050869:c709191-708577 [Saccharolobus solfataricus]
MLKSPFEATILIEEHPCEVMKIISSTGLKGVVDNVKLGDNTTDHIVLFEKEVQKDDLIKLKSHSTKVLRLNDNKIWVRTY
GCAVCKILYTSNVVVEKIKVVRERTLLYTLLIPNTMALKEFLASLISQDIEFTVLSTSEISSNELTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISTPTLEEILRRALRKVVKFYLDKVR

Download         Length: 615 bp

>T153433 NZ_CP066906:5550-5966 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13662.96 Da        Isoelectric Point: 9.9061

>AT153433 WP_009988464.1 NZ_CP050869:c709556-709209 [Saccharolobus solfataricus]
MIKLKRVYDPIERDDGIRILVDRLWPRGIGKDKVDLWLKDIAPSDELRKWFSHDTSKWDEFKKKYFEELDANPKISVLLQ
LIKKGENITLLYASKSPYNNAVALKEYLEKKILKQ

Download         Length: 348 bp

>AT153433 NZ_CP066906:5323-5553 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E3MDP8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E3GU05

References