Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1314639..1315257 Replicon chromosome
Accession NZ_CP050865
Organism Escherichia coli strain 8-3-Ti3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HFC66_RS06645 Protein ID WP_001291435.1
Coordinates 1315039..1315257 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HFC66_RS06640 Protein ID WP_112013726.1
Coordinates 1314639..1315013 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFC66_RS06630 1309728..1310921 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HFC66_RS06635 1310944..1314093 + 3150 WP_032359079.1 multidrug efflux RND transporter permease subunit -
HFC66_RS06640 1314639..1315013 + 375 WP_112013726.1 Hha toxicity modulator TomB Antitoxin
HFC66_RS06645 1315039..1315257 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HFC66_RS06650 1315429..1315980 + 552 WP_000102569.1 maltose O-acetyltransferase -
HFC66_RS06655 1316096..1316566 + 471 WP_000136192.1 YlaC family protein -
HFC66_RS06660 1316730..1318280 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HFC66_RS06665 1318322..1318675 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HFC66_RS06675 1319054..1319365 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1319395..1320723 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153408 WP_001291435.1 NZ_CP050865:1315039-1315257 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153408 NZ_CP066900:2025248-2025350 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.48 Da        Isoelectric Point: 4.7395

>AT153408 WP_112013726.1 NZ_CP050865:1314639-1315013 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNAMKENPASLSC

Download         Length: 375 bp

>AT153408 NZ_CP066900:c2025357-2025212 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References