Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 192183..192742 Replicon plasmid unnamed1
Accession NZ_CP050863
Organism Escherichia coli strain 8-3-DC15

Toxin (Protein)


Gene name relE Uniprot ID D2AJT2
Locus tag HFC67_RS26070 Protein ID WP_000421262.1
Coordinates 192467..192742 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M1UJH5
Locus tag HFC67_RS26065 Protein ID WP_038341659.1
Coordinates 192183..192467 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFC67_RS26025 188172..188441 - 270 Protein_220 transposase -
HFC67_RS26030 188556..189194 - 639 WP_000607008.1 type III secretion system effector OspI -
HFC67_RS26035 189347..189439 - 93 Protein_222 IS1 family transposase -
HFC67_RS26040 189492..190189 + 698 Protein_223 IS1 family transposase -
HFC67_RS26045 190202..190600 - 399 Protein_224 IS1 family transposase -
HFC67_RS26050 190936..191121 + 186 Protein_225 ATP-binding protein -
HFC67_RS26055 191221..191430 - 210 Protein_226 peptidoglycan-binding protein -
HFC67_RS26060 191480..191659 - 180 Protein_227 MFS transporter -
HFC67_RS26065 192183..192467 + 285 WP_038341659.1 ribbon-helix-helix domain-containing protein Antitoxin
HFC67_RS26070 192467..192742 + 276 WP_000421262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFC67_RS26465 192874..193011 - 138 WP_000766699.1 hypothetical protein -
HFC67_RS26080 193118..193469 - 352 Protein_231 plasmid partitioning/stability family protein -
HFC67_RS26085 193472..194040 - 569 Protein_232 plasmid segregation protein ParM -
HFC67_RS26090 194048..195139 + 1092 Protein_233 IS66 family transposase -
HFC67_RS26095 195334..196542 - 1209 Protein_234 IS91 family transposase -
HFC67_RS26100 196523..196795 - 273 WP_000019158.1 hypothetical protein -
HFC67_RS26105 196955..197173 + 219 WP_000813626.1 type II toxin-antitoxin system antitoxin CcdA -
HFC67_RS26110 197175..197480 + 306 WP_001159860.1 type II toxin-antitoxin system toxin CcdB -
HFC67_RS26115 197516..197611 + 96 Protein_238 transposase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospC2 / nleE / icsP/sopA / ospB / ospC4 / ospC4 / ospC2 / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH7.8 / ipaH1.4 / ospE2 / senB / faeF / faeH / faeI / ospC1 / ospD3/senA / ospC2 / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ospI / ipaH9.8 / ospG 1..233798 233798
- inside IScluster/Tn - ospI / ipaH9.8 / ospG 180696..201242 20546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10766.48 Da        Isoelectric Point: 9.9324

>T153405 WP_000421262.1 NZ_CP050863:192467-192742 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T153405 NZ_CP066900:353992-354339 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10444.88 Da        Isoelectric Point: 5.5648

>AT153405 WP_038341659.1 NZ_CP050863:192183-192467 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEECNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR

Download         Length: 285 bp

>AT153405 NZ_CP066900:354339-354638 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822PVM3

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1UJH5

References