Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3067017..3067635 Replicon chromosome
Accession NZ_CP050862
Organism Escherichia coli strain 8-3-DC15

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HFC67_RS15785 Protein ID WP_001291435.1
Coordinates 3067417..3067635 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HFC67_RS15780 Protein ID WP_112013726.1
Coordinates 3067017..3067391 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFC67_RS15770 3062106..3063299 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HFC67_RS15775 3063322..3066471 + 3150 WP_032359079.1 multidrug efflux RND transporter permease subunit -
HFC67_RS15780 3067017..3067391 + 375 WP_112013726.1 Hha toxicity modulator TomB Antitoxin
HFC67_RS15785 3067417..3067635 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
HFC67_RS15790 3067807..3068358 + 552 WP_000102569.1 maltose O-acetyltransferase -
HFC67_RS15795 3068474..3068944 + 471 WP_000136192.1 YlaC family protein -
HFC67_RS15800 3069108..3070658 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HFC67_RS15805 3070700..3071053 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HFC67_RS15815 3071432..3071743 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3071773..3073101 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153397 WP_001291435.1 NZ_CP050862:3067417-3067635 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153397 NZ_CP066896:95799-96290 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.48 Da        Isoelectric Point: 4.7395

>AT153397 WP_112013726.1 NZ_CP050862:3067017-3067391 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNAMKENPASLSC

Download         Length: 375 bp

>AT153397 NZ_CP066896:95545-95811 [Klebsiella pneumoniae]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References