Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1563731..1564388 Replicon chromosome
Accession NZ_CP050858
Organism Klebsiella pneumoniae strain SCH6109

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HC233_RS07775 Protein ID WP_167835519.1
Coordinates 1563978..1564388 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HC233_RS07770 Protein ID WP_002916312.1
Coordinates 1563731..1563997 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC233_RS07745 1558887..1560320 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HC233_RS07750 1560439..1561167 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HC233_RS07755 1561217..1561528 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HC233_RS07760 1561692..1562351 + 660 WP_002916317.1 hemolysin III family protein -
HC233_RS07765 1562502..1563485 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HC233_RS07770 1563731..1563997 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HC233_RS07775 1563978..1564388 + 411 WP_167835519.1 protein YgfX Toxin
HC233_RS07780 1564395..1564916 - 522 WP_002916308.1 flavodoxin FldB -
HC233_RS07785 1565017..1565913 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HC233_RS07790 1565936..1566649 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HC233_RS07795 1566655..1568388 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15950.72 Da        Isoelectric Point: 11.4778

>T153369 WP_167835519.1 NZ_CP050858:1563978-1564388 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPSPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T153369 NZ_CP066888:128727-128876 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT153369 WP_002916312.1 NZ_CP050858:1563731-1563997 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153369 NZ_CP066888:c128682-128623 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References