Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 19873..20426 Replicon plasmid pSsAf2.3-1
Accession NZ_CP050856
Organism Serratia symbiotica strain CWBI-2.3

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag SYMBAF_RS16575 Protein ID WP_040265182.1
Coordinates 19873..20187 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag SYMBAF_RS16580 Protein ID WP_040265181.1
Coordinates 20190..20426 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYMBAF_RS16550 15904..16401 + 498 WP_040265206.1 hypothetical protein -
SYMBAF_RS16555 17027..17716 + 690 WP_052447758.1 tyrosine-type recombinase/integrase -
SYMBAF_RS16560 17908..18570 + 663 WP_040265185.1 ParA family protein -
SYMBAF_RS16565 18598..18903 + 306 WP_040265184.1 hypothetical protein -
SYMBAF_RS16570 19019..19675 + 657 WP_052447757.1 DUF4145 domain-containing protein -
SYMBAF_RS16575 19873..20187 - 315 WP_040265182.1 CcdB family protein Toxin
SYMBAF_RS16580 20190..20426 - 237 WP_040265181.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
SYMBAF_RS16585 20873..21082 + 210 WP_040265179.1 hypothetical protein -
SYMBAF_RS16590 21128..21334 - 207 Protein_24 hypothetical protein -
SYMBAF_RS16595 21518..21853 - 336 WP_152609113.1 hypothetical protein -
SYMBAF_RS16600 21955..23123 + 1169 WP_152609001.1 IS3 family transposase -
SYMBAF_RS16605 23642..25153 - 1512 WP_052447755.1 DHA2 family efflux MFS transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pilW 1..82638 82638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11740.70 Da        Isoelectric Point: 5.6692

>T153360 WP_040265182.1 NZ_CP050856:c20187-19873 [Serratia symbiotica]
MQFTVYSNTGKSAIYPLLLDVTSDIIDQLNRRIVIPLLPVEKYPGNTRPERLVPLVRLTDDKEYAVMTHEMASIPVRSLG
EVFCDASLHRIQIKAAIDFLLDGI

Download         Length: 315 bp

>T153360 NZ_CP066887:875729-876136 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8952.92 Da        Isoelectric Point: 4.8040

>AT153360 WP_040265181.1 NZ_CP050856:c20426-20190 [Serratia symbiotica]
MATTQRATQSVTMTVERTLLSRAREAGINLSATLITALDAELRQYEAKKWQEENSEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT153360 NZ_CP066887:875482-875748 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References