Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2639232..2640915 Replicon chromosome
Accession NZ_CP050855
Organism Serratia symbiotica strain CWBI-2.3

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag SYMBAF_RS13230 Protein ID WP_040262818.1
Coordinates 2639232..2640149 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag SYMBAF_RS13235 Protein ID WP_040262816.1
Coordinates 2640142..2640915 (-) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYMBAF_RS13190 2634701..2635609 - 909 WP_040262899.1 sulfate adenylyltransferase subunit CysD -
SYMBAF_RS13195 2635632..2637062 - 1431 WP_040262825.1 siroheme synthase CysG -
SYMBAF_RS13200 2637115..2637417 - 303 WP_175576940.1 hypothetical protein -
SYMBAF_RS13205 2637377..2637835 - 459 WP_040262821.1 hypothetical protein -
SYMBAF_RS13210 2637939..2638205 - 267 WP_082026805.1 Txe/YoeB family addiction module toxin -
SYMBAF_RS13215 2638202..2638447 - 246 WP_006708173.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SYMBAF_RS13220 2638514..2638693 - 180 WP_152609008.1 hypothetical protein -
SYMBAF_RS13225 2638709..2638954 - 246 WP_052447611.1 hypothetical protein -
SYMBAF_RS13230 2639232..2640149 - 918 WP_040262818.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
SYMBAF_RS13235 2640142..2640915 - 774 WP_040262816.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
SYMBAF_RS13240 2641520..2642800 - 1281 WP_040262814.1 site-specific integrase -
SYMBAF_RS13245 2643036..2643287 - 252 WP_185899907.1 hypothetical protein -
SYMBAF_RS13250 2643600..2644328 - 729 WP_040262810.1 phosphoadenylyl-sulfate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2639232..2649774 10542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-233)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34379.74 Da        Isoelectric Point: 4.9355

>T153359 WP_040262818.1 NZ_CP050855:c2640149-2639232 [Serratia symbiotica]
MDSQSPYYRQVALLLSVLPVVASERCFALKGGTAINLFIRDFPRLSVDIDLAYILLESREVALPSVRDALMRIAKILQQQ
AGISAVLQTNNPDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDVVEAVEDEFGFATIQVASLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRHIFNGFITYLLGHPRPISEVLNPRWKDISGLYANEFNGMTFDAVSLEELNAIPNLMVIALKA
QFTLRDYDFLMSFKSGQPDWSLAPEDQIQYLPAVKWKLLNIGRMPKDKHIQALAKLDAVLAEWIR

Download         Length: 918 bp

>T153359 NZ_CP066887:741467-741952 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 28894.27 Da        Isoelectric Point: 10.0285

>AT153359 WP_040262816.1 NZ_CP050855:c2640915-2640142 [Serratia symbiotica]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGREPKWSDAVLCLQNQLGVSVHLAGLT
SLTYQGRSHYLHLTRQTIWLCVGDKVSLPKWFKEFPNVEWLVLSNQKLNMHDEKYLTEVEIKGERLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWGKRIDKTNIDLGAGKRQIISGGKLDQK
YQITVPDSFVSKGISHG

Download         Length: 774 bp

>AT153359 NZ_CP066887:741177-741470 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References