Detailed information of TA system TA153357

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2524175..2524844
• Replicon: chromosome
• Accession: NZ_CP050855
• Organism: Serratia symbiotica strain CWBI-2.3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: SYMBAF_RS12645
• Protein ID: WP_040266965.1
• Coordinates: 2524175..2524597 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: E9CNM3
• Locus tag: SYMBAF_RS12650
• Protein ID: WP_006709290.1
• Coordinates: 2524578..2524844 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYMBAF_RS12625	2519903..2521633	-	1731	WP_040266962.1	single-stranded-DNA-specific exonuclease RecJ	-
SYMBAF_RS12630	2521640..2522356	-	717	WP_040266963.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
SYMBAF_RS12635	2522369..2523268	-	900	WP_006709292.1	site-specific tyrosine recombinase XerD	-
SYMBAF_RS12640	2523511..2524029	+	519	WP_040266964.1	flavodoxin FldB	-
SYMBAF_RS12645	2524175..2524597	-	423	WP_040266965.1	protein YgfX	Toxin
SYMBAF_RS12650	2524578..2524844	-	267	WP_006709290.1	FAD assembly factor SdhE	Antitoxin
SYMBAF_RS12655	2525177..2526163	+	987	WP_006709289.1	tRNA-modifying protein YgfZ	-
SYMBAF_RS12660	2526443..2527117	-	675	WP_040266967.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16783.77 Da
• Isoelectric Point: 10.0541

>T153357 WP_040266965.1 NZ_CP050855:c2524597-2524175 [Serratia symbiotica]
VAQWRCDVRISRRTQLFSLLTHGVLVLLILISPWPAGYGPIWLVLLILVVFQGIRSQKRLAAVQGELRLLADWRINWHGR
EWRLVKKPWMPDYGILLTLHPMEGNKYQRLWLVLDNMEREEWRYLRQRLLYPPVSDDEET

Nucleotide

• Length: 423 bp

>T153357 NZ_CP066887:329307-329675 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10401.91 Da
• Isoelectric Point: 4.8052

>AT153357 WP_006709290.1 NZ_CP050855:c2524844-2524578 [Serratia symbiotica]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDQLNDTDKALFIRLLECDDPDLFNWLMNHGAPEDSELQRMVALIQSRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT153357 NZ_CP066887:329089-329310 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A068Z5F1