Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 2470809..2471443 Replicon chromosome
Accession NZ_CP050855
Organism Serratia symbiotica strain CWBI-2.3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SYMBAF_RS12375 Protein ID WP_040266910.1
Coordinates 2470809..2470985 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SYMBAF_RS12380 Protein ID WP_040266912.1
Coordinates 2471036..2471443 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYMBAF_RS12345 2466105..2466501 - 397 Protein_2415 IS200/IS605 family transposase -
SYMBAF_RS12355 2467739..2468263 - 525 Protein_2417 integrase arm-type DNA-binding domain-containing protein -
SYMBAF_RS12365 2468994..2469860 + 867 WP_040266905.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -
SYMBAF_RS12370 2469960..2470663 + 704 Protein_2419 IS6 family transposase -
SYMBAF_RS12375 2470809..2470985 + 177 WP_040266910.1 type II toxin-antitoxin system HicA family toxin Toxin
SYMBAF_RS12380 2471036..2471443 + 408 WP_040266912.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SYMBAF_RS12385 2471521..2471848 + 328 Protein_2422 phage holin, lambda family -
SYMBAF_RS12390 2471845..2472258 + 414 WP_040266915.1 structural protein -
SYMBAF_RS12395 2472261..2472717 + 457 Protein_2424 lysis protein -
SYMBAF_RS12400 2472778..2473737 + 960 WP_040266916.1 hypothetical protein -
SYMBAF_RS12405 2474275..2474733 - 459 WP_052447854.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2465641..2475898 10257
- inside IScluster/Tn - - 2466498..2476485 9987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(79-131)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6619.79 Da        Isoelectric Point: 11.1475

>T153356 WP_040266910.1 NZ_CP050855:2470809-2470985 [Serratia symbiotica]
VKQSEFRRWLAAQGAEFKDGTNHLKIILNSKQTVMPRHPGKEIPEPLRKAILKQLGIT

Download         Length: 177 bp

>T153356 NZ_CP066885:802539-802892 [Staphylococcus pseudintermedius]
ATGAAGCGCGGAGACGTTTATTTAGCAGATTTATCACCAGTACAGGGCTCTGAACAGGGGGGAGTAAGGCCCGTTGTCAT
TATTCAAAATGACACTGGTAATAAGTATAGTCCCACTGTGATTGTAGCCGCAATTACTGGTCGGATTAATAAGGCAAAGA
TACCAACGCATGTCGAAATCGAAAAAAATAAATATAAGCTCGATAAAGATTCTGTTATTTTACTAGAACAAATTCGAACA
GTCGATAAGAAACGATTAAAAGAAAAGTTAACGTTTTTGTCTGAGAAGAAGATGAAAGAAGTTAACAATGCGATTGGTAT
TAGTTTAGGACTGCACATGAATCATCATAAATAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14884.05 Da        Isoelectric Point: 4.6363

>AT153356 WP_040266912.1 NZ_CP050855:2471036-2471443 [Serratia symbiotica]
MRYPVKFEHDETGWCVSFPDIPEALTGGDTREEAIEMAQDALVTAFDFYFEDRRPVPMPSANGEEFIDVPASVAAKVLLL
NAMIATGTTPAQLARRLGTRPQEVNRIVTLNHATKIDTIEAALKALGKRLEITVL

Download         Length: 408 bp

>AT153356 NZ_CP066885:802368-802538 [Staphylococcus pseudintermedius]
ATGTCAGCATTCAATCAAACAAGATTTAAAAATTTAGAACAGTCGTTAAAAGAAGGTTATGTACAGATGGCAGATTTAAA
TCTCTCCCTAGCCACTGAGGCGTATCCAGTTGAATGTGAAGCTTGCGATTGTAATGAATCACACTTGACAACTGATTACA
AGGAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References