Detailed information of TA system TA153354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2239444..2240107
• Replicon: chromosome
• Accession: NZ_CP050855
• Organism: Serratia symbiotica strain CWBI-2.3

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: SYMBAF_RS11210
• Protein ID: WP_040266579.1
• Coordinates: 2239444..2239788 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: SYMBAF_RS11215
• Protein ID: WP_040266580.1
• Coordinates: 2239790..2240107 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYMBAF_RS11180	2236488..2237174	-	687	Protein_2191	phage portal protein	-
SYMBAF_RS11185	2237172..2237576	+	405	Protein_2192	P2 family phage major capsid protein	-
SYMBAF_RS11190	2237573..2238235	+	663	WP_040266571.1	terminase	-
SYMBAF_RS11195	2238322..2238789	+	468	WP_040266572.1	head completion/stabilization protein	-
SYMBAF_RS11200	2238906..2239142	+	237	WP_040266575.1	hypothetical protein	-
SYMBAF_RS11205	2239142..2239348	+	207	WP_040266577.1	hypothetical protein	-
SYMBAF_RS11210	2239444..2239788	+	345	WP_040266579.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SYMBAF_RS11215	2239790..2240107	+	318	WP_040266580.1	helix-turn-helix domain-containing protein	Antitoxin
SYMBAF_RS11220	2240141..2240518	-	378	WP_040266582.1	type II toxin-antitoxin system death-on-curing family toxin	-
SYMBAF_RS11225	2240749..2240928	-	180	WP_040266586.1	phage protein	-
SYMBAF_RS11230	2241063..2241269	+	207	WP_040266588.1	hypothetical protein	-
SYMBAF_RS11235	2241259..2241564	+	306	WP_040266591.1	hypothetical protein	-
SYMBAF_RS11240	2241679..2241882	+	204	WP_040266592.1	tail protein X	-
SYMBAF_RS11245	2241885..2242262	+	378	WP_040266594.1	phage holin family protein	-
SYMBAF_RS11250	2242259..2242576	+	318	WP_040266595.1	phage holin family protein	-
SYMBAF_RS11255	2242554..2243144	+	591	WP_040266597.1	N-acetylmuramidase family protein	-
SYMBAF_RS11260	2243141..2243590	+	450	WP_040266598.1	Rz-like lysis system protein LysB	-
SYMBAF_RS11265	2243686..2244144	+	459	WP_040266599.1	phage tail protein	-
SYMBAF_RS11270	2244144..2244590	+	447	Protein_2209	phage virion morphogenesis protein	-
SYMBAF_RS11275	2244663..2244926	+	264	WP_040266600.1	type II toxin-antitoxin system HicA family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2214739..2254345	39606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12499.21 Da
• Isoelectric Point: 9.5629

>T153354 WP_040266579.1 NZ_CP050855:2239444-2239788 [Serratia symbiotica]
MKPLYWVGSSKKDLQSLPDDVQDVFGYALHLAQAGGKHSLTKPLKGFGGAGVLEVEEDYLGDTYRAVYTVRFGNAVYVLH
AFQKKSSSGISTPKPDMDKIRERLKTAENHAKGA

Nucleotide

• Length: 345 bp

>T153354 NZ_CP066885:177859-178125 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTTTTAATTAAGAATTCAGCCAAAAATGACTTAAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGATGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTTCTGCTTGGTCACATTATGAGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11536.46 Da
• Isoelectric Point: 10.6932

>AT153354 WP_040266580.1 NZ_CP050855:2239790-2240107 [Serratia symbiotica]
MSHDIEVSSGNVYADIGRNDAEEMLVKAQLATTIGNIIKSRRLTQEQAAKLLGITQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSLKVVFA

Nucleotide

• Length: 318 bp

>AT153354 NZ_CP066885:177602-177859 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA