Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374265..374840 Replicon chromosome
Accession NZ_CP050855
Organism Serratia symbiotica strain CWBI-2.3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag SYMBAF_RS01915 Protein ID WP_152609074.1
Coordinates 374265..374591 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag SYMBAF_RS01920 Protein ID WP_040264654.1
Coordinates 374592..374840 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYMBAF_RS01885 369409..370827 + 1419 WP_052447689.1 integrating conjugative element protein -
SYMBAF_RS01890 370829..371176 + 348 WP_040264650.1 hypothetical protein -
SYMBAF_RS01895 371178..372698 + 1521 WP_040264651.1 conjugal transfer protein TraG N-terminal domain-containing protein -
SYMBAF_RS01900 372745..372972 - 228 WP_040264652.1 hypothetical protein -
SYMBAF_RS01905 373481..373849 - 369 Protein_372 transposase -
SYMBAF_RS01910 373943..374233 - 291 WP_040264653.1 hypothetical protein -
SYMBAF_RS01915 374265..374591 - 327 WP_152609074.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SYMBAF_RS01920 374592..374840 - 249 WP_040264654.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SYMBAF_RS01925 375386..375757 + 372 Protein_376 conjugal transfer protein TraG -
SYMBAF_RS01930 375892..377217 + 1326 WP_040264655.1 restriction endonuclease subunit M -
SYMBAF_RS01935 377315..379384 + 2070 WP_082026891.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 373442..386249 12807
- flank IS/Tn - - 373442..373849 407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12466.71 Da        Isoelectric Point: 10.4792

>T153350 WP_152609074.1 NZ_CP050855:c374591-374265 [Serratia symbiotica]
MSGTALKTRLKFKKSALKEWNALDSKIRETFRKKLKKRAESLAALTPIKHKLSGVEKCYKIKLRMDGFRLVYHVLESDDG
EVDVVITVITVDRREDVYEALKSKLVKD

Download         Length: 327 bp

>T153350 NZ_CP066853:c4885686-4885438 [Rhodococcus biphenylivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAGAACTTCTTTCCGCTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAACACACCGAAAGGGAACTC
ATCGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9045.33 Da        Isoelectric Point: 4.5183

>AT153350 WP_040264654.1 NZ_CP050855:c374840-374592 [Serratia symbiotica]
MITAILANRSATISELKKNPTAIVMSAGGRPVAILNHSKPSFYCIPAELYAAMLDAIEDRELANIVRSRQDEDEVDVSWE
NL

Download         Length: 249 bp

>AT153350 NZ_CP066853:c4885441-4885187 [Rhodococcus biphenylivorans]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAGCAGCTCGAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References