Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4822121..4822648 Replicon chromosome
Accession NZ_CP050854
Organism Brenneria izadpanahii strain Iran 50

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HC231_RS21560 Protein ID WP_208228710.1
Coordinates 4822373..4822648 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HC231_RS21555 Protein ID WP_208228709.1
Coordinates 4822121..4822369 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC231_RS21520 (HC231_21530) 4817805..4818170 + 366 WP_208228704.1 hypothetical protein -
HC231_RS21525 (HC231_21535) 4818213..4818620 + 408 WP_116162565.1 hypothetical protein -
HC231_RS21530 (HC231_21540) 4818948..4819769 + 822 WP_208228705.1 DUF932 domain-containing protein -
HC231_RS21535 (HC231_21545) 4819822..4820295 + 474 WP_208228706.1 DNA repair protein RadC -
HC231_RS21540 (HC231_21550) 4820335..4820670 + 336 WP_208228707.1 type IV toxin-antitoxin system YeeU family antitoxin -
HC231_RS21545 (HC231_21555) 4820740..4821060 + 321 WP_130640181.1 TA system toxin CbtA family protein -
HC231_RS21550 (HC231_21560) 4821178..4822011 + 834 WP_208228708.1 DUF4942 domain-containing protein -
HC231_RS21555 (HC231_21565) 4822121..4822369 + 249 WP_208228709.1 ribbon-helix-helix domain-containing protein Antitoxin
HC231_RS21560 (HC231_21570) 4822373..4822648 + 276 WP_208228710.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC231_RS21565 (HC231_21575) 4822776..4823693 + 918 WP_208228711.1 hypothetical protein -
HC231_RS24075 4823926..4824084 + 159 WP_246494612.1 helix-turn-helix domain-containing protein -
HC231_RS21570 (HC231_21580) 4824077..4824721 + 645 WP_246494614.1 transcriptional regulator -
HC231_RS21575 (HC231_21585) 4825330..4825710 - 381 WP_208231466.1 DUF1493 family protein -
HC231_RS21580 (HC231_21590) 4825895..4826268 - 374 Protein_4250 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4812703..4838261 25558
- flank IS/Tn - - 4826029..4826268 239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10989.22 Da        Isoelectric Point: 5.1487

>T153348 WP_208228710.1 NZ_CP050854:4822373-4822648 [Brenneria izadpanahii]
MEIRWTQKAQDDLERIYGFASQYSRQHADEVLDRLIIGTTGLADHPRIGVSQARYEPREVRKILFDDYEVHYEIQHDTIY
IVDLWHTREDR

Download         Length: 276 bp

>T153348 NZ_CP066853:c2638383-2637814 [Rhodococcus biphenylivorans]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGACCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8983.32 Da        Isoelectric Point: 7.2045

>AT153348 WP_208228709.1 NZ_CP050854:4822121-4822369 [Brenneria izadpanahii]
MGQSAKQTISAQIPAELAAAVESLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVIDFANKLK
KS

Download         Length: 249 bp

>AT153348 NZ_CP066853:c2638766-2638380 [Rhodococcus biphenylivorans]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGTGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAGTACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCTCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGGTTCTCGCCGCGCGTGGGGTCAGCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References