Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4820335..4821060 Replicon chromosome
Accession NZ_CP050854
Organism Brenneria izadpanahii strain Iran 50

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HC231_RS21545 Protein ID WP_130640181.1
Coordinates 4820740..4821060 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HC231_RS21540 Protein ID WP_208228707.1
Coordinates 4820335..4820670 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC231_RS21510 (HC231_21520) 4816244..4816975 + 732 WP_208231464.1 DUF3944 domain-containing protein -
HC231_RS21515 (HC231_21525) 4817030..4817707 + 678 WP_208228703.1 WYL domain-containing protein -
HC231_RS21520 (HC231_21530) 4817805..4818170 + 366 WP_208228704.1 hypothetical protein -
HC231_RS21525 (HC231_21535) 4818213..4818620 + 408 WP_116162565.1 hypothetical protein -
HC231_RS21530 (HC231_21540) 4818948..4819769 + 822 WP_208228705.1 DUF932 domain-containing protein -
HC231_RS21535 (HC231_21545) 4819822..4820295 + 474 WP_208228706.1 DNA repair protein RadC -
HC231_RS21540 (HC231_21550) 4820335..4820670 + 336 WP_208228707.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HC231_RS21545 (HC231_21555) 4820740..4821060 + 321 WP_130640181.1 TA system toxin CbtA family protein Toxin
HC231_RS21550 (HC231_21560) 4821178..4822011 + 834 WP_208228708.1 DUF4942 domain-containing protein -
HC231_RS21555 (HC231_21565) 4822121..4822369 + 249 WP_208228709.1 ribbon-helix-helix domain-containing protein -
HC231_RS21560 (HC231_21570) 4822373..4822648 + 276 WP_208228710.1 type II toxin-antitoxin system RelE/ParE family toxin -
HC231_RS21565 (HC231_21575) 4822776..4823693 + 918 WP_208228711.1 hypothetical protein -
HC231_RS24075 4823926..4824084 + 159 WP_246494612.1 helix-turn-helix domain-containing protein -
HC231_RS21570 (HC231_21580) 4824077..4824721 + 645 WP_246494614.1 transcriptional regulator -
HC231_RS21575 (HC231_21585) 4825330..4825710 - 381 WP_208231466.1 DUF1493 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4812703..4838261 25558
- flank IS/Tn - - 4826029..4826268 239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12120.92 Da        Isoelectric Point: 4.7768

>T153347 WP_130640181.1 NZ_CP050854:4820740-4821060 [Brenneria izadpanahii]
MQTSPAIPPREDIPCPSPVVVWQQLLTYLLEKHYGLTLNDTPFCEENVIQEHIDAGITLVNAVNFLVEKYELVRIDRNGF
NWQEQSPFLTTVDILRARRATGLLKA

Download         Length: 321 bp

>T153347 NZ_CP066853:654635-654913 [Rhodococcus biphenylivorans]
ATGAGCACTCCGGACCACCCGTATCGGCTGGTGATGGCGAGGTCGGCTGCACGCGCCATGGCGAGGTCGTTGCCGGAGAA
AGTAGCAACTGCGGTATACGAGTTCGTCACAGGGCCCCTTCTCGAGAATCCGAAGCGGGTGGGGAAGCCGTTGAATCCGC
CTCTTGCGCCGGCGTACAGCGCCCGGCGAGGTGAATATCGCGTCCTGTATCTGATCGATGATGCGAACCGCACGGTCGAG
GTCACCGCGATTTCGCACCGTGCCGATGCGTATCGATAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.97 Da        Isoelectric Point: 4.8039

>AT153347 WP_208228707.1 NZ_CP050854:4820335-4820670 [Brenneria izadpanahii]
MPSSDTPEWGLKRAVTPQFGARLIQEGNYLHYLADRASVVGTFSETEARYLEQSFPELIKQLEQKLRTGELNPRQQGCIT
LHCNEWTCEADTQGSFGYVYIAIYPSSAATQ

Download         Length: 336 bp

>AT153347 NZ_CP066853:654348-654638 [Rhodococcus biphenylivorans]
ATGTACATGACGACTCTTCCTGTTGCCGACGCGCGGGCGCAATTGTCACGACTGGTCGATGAGGCCGAGCGCACACACGA
GCGATTCGAGATCACCCGCAACGGGCACCGCGCCGCGGTGCTTCTCGGTGCCGACGATTACGACGCGATGCAGGAGACGA
TCGCGGTGTTGTCGGATACGGATCTGCTGCGGGCGCACGTCGAGGGCCGAACGGAGGTCGAGTCGGGAGACGTCGTCGAT
GTACAGGAATTGACGCAGCTGATGCGTGATGCTCGGTCGTCCGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References