Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4661109..4661635 Replicon chromosome
Accession NZ_CP050854
Organism Brenneria izadpanahii strain Iran 50

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HC231_RS20845 Protein ID WP_208228582.1
Coordinates 4661330..4661635 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HC231_RS20840 Protein ID WP_208228581.1
Coordinates 4661109..4661327 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC231_RS20810 (HC231_20820) 4656592..4656924 + 333 WP_208228578.1 divalent cation tolerance protein CutA -
HC231_RS20815 (HC231_20825) 4656900..4658618 + 1719 WP_208228579.1 protein-disulfide reductase DsbD -
HC231_RS20820 (HC231_20830) 4658932..4659507 + 576 WP_208228580.1 transcriptional regulator -
HC231_RS20830 (HC231_20840) 4659873..4660601 + 729 Protein_4099 integrase arm-type DNA-binding domain-containing protein -
HC231_RS20835 (HC231_20845) 4660577..4661050 + 474 Protein_4100 MobC family replication-relaxation protein -
HC231_RS20840 (HC231_20850) 4661109..4661327 + 219 WP_208228581.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HC231_RS20845 (HC231_20855) 4661330..4661635 + 306 WP_208228582.1 type II toxin-antitoxin system toxin CcdB Toxin
HC231_RS20855 (HC231_20865) 4663110..4663364 + 255 Protein_4104 IS3 family transposase -
HC231_RS20860 (HC231_20870) 4663487..4665838 + 2352 WP_208228583.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11718.58 Da        Isoelectric Point: 4.6627

>T153346 WP_208228582.1 NZ_CP050854:4661330-4661635 [Brenneria izadpanahii]
MQFIVYQYKRASHYTMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKVLFPLIRIDGEDYRLMTTELSSVPVEVIGEAI
ADLGEYADEIKDAINLMFWGI

Download         Length: 306 bp

>T153346 NZ_CP066852:c34664-34383 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8201.16 Da        Isoelectric Point: 7.2038

>AT153346 WP_208228581.1 NZ_CP050854:4661109-4661327 [Brenneria izadpanahii]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEAWKKENREGMEEVARFIEQHGSFADENRNW

Download         Length: 219 bp

>AT153346 NZ_CP066852:c34905-34654 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References