Detailed information of TA system TA153345

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4474013..4474670
• Replicon: chromosome
• Accession: NZ_CP050854
• Organism: Brenneria izadpanahii strain Iran 50

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HC231_RS19915
• Protein ID: WP_208228417.1
• Coordinates: 4474013..4474423 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HC231_RS19920
• Protein ID: WP_208228418.1
• Coordinates: 4474404..4474670 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC231_RS19885 (HC231_19895)	4469482..4469952	-	471	WP_246494585.1	DUF943 family protein	-
HC231_RS19890 (HC231_19900)	4470081..4470551	-	471	WP_246494586.1	DUF943 family protein	-
HC231_RS19895 (HC231_19905)	4470625..4471095	-	471	WP_208228413.1	DUF943 family protein	-
HC231_RS19900 (HC231_19910)	4471092..4471952	-	861	WP_208228414.1	DUF3289 family protein	-
HC231_RS19905 (HC231_19915)	4472251..4472769	+	519	WP_208228415.1	flavodoxin FldB	-
HC231_RS19910 (HC231_19920)	4472819..4473772	-	954	WP_208228416.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
HC231_RS19915 (HC231_19925)	4474013..4474423	-	411	WP_208228417.1	protein YgfX	Toxin
HC231_RS19920 (HC231_19930)	4474404..4474670	-	267	WP_208228418.1	FAD assembly factor SdhE	Antitoxin
HC231_RS19925 (HC231_19935)	4474888..4475877	+	990	WP_208228419.1	tRNA-modifying protein YgfZ	-
HC231_RS19930 (HC231_19940)	4475923..4476570	-	648	WP_208228420.1	hemolysin III family protein	-
HC231_RS19935 (HC231_19945)	4476913..4477521	+	609	WP_208228421.1	HD domain-containing protein	-
HC231_RS19940 (HC231_19950)	4477645..4478952	-	1308	WP_208228422.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16116.03 Da
• Isoelectric Point: 11.6833

>T153345 WP_208228417.1 NZ_CP050854:c4474423-4474013 [Brenneria izadpanahii]
VAQWQCDLRVSWRMQLFSLVVHGLLVLLILLAPWPDSYTVLWLGMVTLVVFGFIRSQRNIKSRQGEILLRSATRLRWQQQ
EWLITKRPWMLKNGVLLSLKAIDGKGRQRLWLASDSMGDDEWRHLRQLLQHKSWAQ

Nucleotide

• Length: 411 bp

>T153345 NZ_CP066851:4565899-4566210 [Salmonella enterica subsp. enterica serovar Heidelberg]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10493.97 Da
• Isoelectric Point: 6.2141

>AT153345 WP_208228418.1 NZ_CP050854:c4474670-4474404 [Brenneria izadpanahii]
MEIDNKSRIHWACRRGMRELDISIMPFFTHDYDALSDDDKRAFVRLLQCDDPDLFNWLMNHGEPQDQDLKRMISLIQTRN
KNRGPVAM

Nucleotide

• Length: 267 bp

>AT153345 NZ_CP066851:4566207-4566653 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG