Detailed information of TA system TA153344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4305590..4306115
• Replicon: chromosome
• Accession: NZ_CP050854
• Organism: Brenneria izadpanahii strain Iran 50

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC231_RS19215
• Protein ID: WP_208228307.1
• Coordinates: 4305831..4306115 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HC231_RS19210
• Protein ID: WP_208228306.1
• Coordinates: 4305590..4305841 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC231_RS19170 (HC231_19175)	4300937..4301416	-	480	WP_208228300.1	GNAT family N-acetyltransferase	-
HC231_RS19175 (HC231_19180)	4301407..4301679	-	273	WP_208228301.1	DUF1778 domain-containing protein	-
HC231_RS19180 (HC231_19185)	4302339..4303019	+	681	WP_208228302.1	hypothetical protein	-
HC231_RS19185 (HC231_19190)	4303100..4303483	+	384	WP_208228303.1	hypothetical protein	-
HC231_RS19190 (HC231_19195)	4303719..4304267	+	549	WP_208228304.1	hypothetical protein	-
HC231_RS19195 (HC231_19200)	4304270..4304725	+	456	WP_208228305.1	hypothetical protein	-
HC231_RS19200 (HC231_19205)	4304889..4305105	+	217	Protein_3779	nuclease	-
HC231_RS19205 (HC231_19210)	4305100..4305329	+	230	Protein_3780	winged helix-turn-helix domain-containing protein	-
HC231_RS19210 (HC231_19215)	4305590..4305841	+	252	WP_208228306.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HC231_RS19215 (HC231_19220)	4305831..4306115	+	285	WP_208228307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC231_RS19220 (HC231_19225)	4306556..4306726	+	171	Protein_3783	integrase	-
HC231_RS19225 (HC231_19230)	4306760..4308025	-	1266	WP_208228309.1	alpha-hydroxy-acid oxidizing protein	-
HC231_RS19230 (HC231_19235)	4308436..4310391	+	1956	WP_208228310.1	transporter substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11010.96 Da
• Isoelectric Point: 10.1716

>T153344 WP_208228307.1 NZ_CP050854:4305831-4306115 [Brenneria izadpanahii]
MSYKLEFEEHALKEFKKLGTPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVIEHEIVVLVLAVGK
RERSEVYKAAKDRL

Nucleotide

• Length: 285 bp

>T153344 NZ_CP066851:c4564666-4564355 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9107.41 Da
• Isoelectric Point: 5.0807

>AT153344 WP_208228306.1 NZ_CP050854:4305590-4305841 [Brenneria izadpanahii]
MSVQPILANAVVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT153344 NZ_CP066851:c4564354-4564064 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA