Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4300937..4301679 Replicon chromosome
Accession NZ_CP050854
Organism Brenneria izadpanahii strain Iran 50

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag HC231_RS19170 Protein ID WP_208228300.1
Coordinates 4300937..4301416 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag HC231_RS19175 Protein ID WP_208228301.1
Coordinates 4301407..4301679 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC231_RS19145 (HC231_19150) 4296249..4297490 + 1242 WP_208228296.1 integrase domain-containing protein -
HC231_RS19150 (HC231_19155) 4297726..4297971 + 246 WP_199377716.1 helix-turn-helix transcriptional regulator -
HC231_RS19155 (HC231_19160) 4298763..4299641 + 879 WP_208228297.1 integrase domain-containing protein -
HC231_RS19160 (HC231_19165) 4299716..4299925 - 210 WP_208228298.1 hypothetical protein -
HC231_RS19165 (HC231_19170) 4300334..4300915 + 582 WP_208228299.1 hypothetical protein -
HC231_RS19170 (HC231_19175) 4300937..4301416 - 480 WP_208228300.1 GNAT family N-acetyltransferase Toxin
HC231_RS19175 (HC231_19180) 4301407..4301679 - 273 WP_208228301.1 DUF1778 domain-containing protein Antitoxin
HC231_RS19180 (HC231_19185) 4302339..4303019 + 681 WP_208228302.1 hypothetical protein -
HC231_RS19185 (HC231_19190) 4303100..4303483 + 384 WP_208228303.1 hypothetical protein -
HC231_RS19190 (HC231_19195) 4303719..4304267 + 549 WP_208228304.1 hypothetical protein -
HC231_RS19195 (HC231_19200) 4304270..4304725 + 456 WP_208228305.1 hypothetical protein -
HC231_RS19200 (HC231_19205) 4304889..4305105 + 217 Protein_3779 nuclease -
HC231_RS19205 (HC231_19210) 4305100..4305329 + 230 Protein_3780 winged helix-turn-helix domain-containing protein -
HC231_RS19210 (HC231_19215) 4305590..4305841 + 252 WP_208228306.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HC231_RS19215 (HC231_19220) 4305831..4306115 + 285 WP_208228307.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(26-146)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17196.74 Da        Isoelectric Point: 9.6037

>T153343 WP_208228300.1 NZ_CP050854:c4301416-4300937 [Brenneria izadpanahii]
VGITAPELLSARHITTDFSCSESSLDEWLKRKALKNQTSGASRTFVVCDADNQHVVGFYALATGSVQRQSAPGAIRRNMP
DPVPVLVLGRLAVDGRYQAKGIGSGLLKDAVLRSRQVAEQVGTKALLVHAISEGAKAFYLHWGFLPSEIQSNTLLLPLW

Download         Length: 480 bp

>T153343 NZ_CP066851:c4062797-4062384 [Salmonella enterica subsp. enterica serovar Heidelberg]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGATTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.77 Da        Isoelectric Point: 4.7064

>AT153343 WP_208228301.1 NZ_CP050854:c4301679-4301407 [Brenneria izadpanahii]
MRIEVKETPINIRAKASQRELIDVAARLQSKSRTDFILEAACREAEEVLLDQRLFLADDSQFDAFIAALEKPVATNERLR
ALLDRTSPWE

Download         Length: 273 bp

>AT153343 NZ_CP066851:c4063044-4062778 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References