Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3887457..3888085 Replicon chromosome
Accession NZ_CP050854
Organism Brenneria izadpanahii strain Iran 50

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag HC231_RS17355 Protein ID WP_009114000.1
Coordinates 3887882..3888085 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HC231_RS17350 Protein ID WP_208227981.1
Coordinates 3887457..3887825 (+) Length 123 a.a.

Genomic Context

HC231_RS17335HC231_RS17340HC231_RS17345HC231_RS17350HC231_RS17355HC231_RS17365HC231_RS17375HC231_RS17370HC231_RS17380HC231_RS17385
Location: 3882944..3886078 (3135 bp)
Type: Others
Protein ID: WP_208227979.1
Location: 3886278..3886526 (249 bp)
Type: Others
Protein ID: WP_048635794.1
Location: 3886730..3886873 (144 bp)
Type: Others
Protein ID: WP_208227980.1
Location: 3887457..3887825 (369 bp)
Type: Antitoxin
Protein ID: WP_208227981.1
Location: 3887882..3888085 (204 bp)
Type: Toxin
Protein ID: WP_009114000.1
Location: 3888903..3889223 (321 bp)
Type: Others
Protein ID: WP_208227982.1
Location: 3890063..3890926 (864 bp)
Type: Others
Protein ID: WP_208227984.1
Location: 3889255..3889809 (555 bp)
Type: Others
Protein ID: WP_208227983.1
Location: 3891025..3892311 (1287 bp)
Type: Others
Protein ID: WP_208227985.1
Location: 3892348..3892686 (339 bp)
Type: Others
Protein ID: WP_002208627.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HC231_RS17335 (HC231_17340)3882944..3886078+3135WP_208227979.1efflux RND transporter permease subunit-
HC231_RS17340 (HC231_17345)3886278..3886526+249WP_048635794.1type B 50S ribosomal protein L31-
HC231_RS17345 (HC231_17350)3886730..3886873+144WP_208227980.1type B 50S ribosomal protein L36-
HC231_RS17350 (HC231_17355)3887457..3887825+369WP_208227981.1Hha toxicity modulator TomBAntitoxin
HC231_RS17355 (HC231_17360)3887882..3888085+204WP_009114000.1HHA domain-containing proteinToxin
HC231_RS17365 (HC231_17370)3888903..3889223+321WP_208227982.1MGMT family protein-
HC231_RS17370 (HC231_17375)3889255..3889809-555WP_208227983.1YbaY family lipoprotein-
HC231_RS17375 (HC231_17380)3890063..3890926+864WP_208227984.1acyl-CoA thioesterase II-
HC231_RS17380 (HC231_17385)3891025..3892311-1287WP_208227985.1ammonium transporter AmtB-
HC231_RS17385 (HC231_17390)3892348..3892686-339WP_002208627.1P-II family nitrogen regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T153342 WP_009114000.1 NZ_CP050854:3887882-3888085 [Brenneria izadpanahii]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T153342 NZ_CP066851:3887694-3888221 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATATTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14053.83 Da        Isoelectric Point: 4.4185

>AT153342 WP_208227981.1 NZ_CP050854:3887457-3887825 [Brenneria izadpanahii]
MDEYTPKHYDIAQLKFLCEYLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPDEGELSQRVEKYL
DDTYVLFSNYGINDAELRGWKKSKERLFGMFSEGDICTPAKT

Download         Length: 369 bp

>AT153342 NZ_CP066851:3887407-3887697 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1X3RNQ0

Antitoxin

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Source
ID
Structure
No matching records found

References