Detailed information of TA system TA153342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3887457..3888085
• Replicon: chromosome
• Accession: NZ_CP050854
• Organism: Brenneria izadpanahii strain Iran 50

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: E0SD87
• Locus tag: HC231_RS17355
• Protein ID: WP_009114000.1
• Coordinates: 3887882..3888085 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: HC231_RS17350
• Protein ID: WP_208227981.1
• Coordinates: 3887457..3887825 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC231_RS17335 (HC231_17340)	3882944..3886078	+	3135	WP_208227979.1	efflux RND transporter permease subunit	-
HC231_RS17340 (HC231_17345)	3886278..3886526	+	249	WP_048635794.1	type B 50S ribosomal protein L31	-
HC231_RS17345 (HC231_17350)	3886730..3886873	+	144	WP_208227980.1	type B 50S ribosomal protein L36	-
HC231_RS17350 (HC231_17355)	3887457..3887825	+	369	WP_208227981.1	Hha toxicity modulator TomB	Antitoxin
HC231_RS17355 (HC231_17360)	3887882..3888085	+	204	WP_009114000.1	HHA domain-containing protein	Toxin
HC231_RS17365 (HC231_17370)	3888903..3889223	+	321	WP_208227982.1	MGMT family protein	-
HC231_RS17370 (HC231_17375)	3889255..3889809	-	555	WP_208227983.1	YbaY family lipoprotein	-
HC231_RS17375 (HC231_17380)	3890063..3890926	+	864	WP_208227984.1	acyl-CoA thioesterase II	-
HC231_RS17380 (HC231_17385)	3891025..3892311	-	1287	WP_208227985.1	ammonium transporter AmtB	-
HC231_RS17385 (HC231_17390)	3892348..3892686	-	339	WP_002208627.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8133.51 Da
• Isoelectric Point: 8.8500

>T153342 WP_009114000.1 NZ_CP050854:3887882-3888085 [Brenneria izadpanahii]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Nucleotide

• Length: 204 bp

>T153342 NZ_CP066851:3887694-3888221 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATATTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14053.83 Da
• Isoelectric Point: 4.4185

>AT153342 WP_208227981.1 NZ_CP050854:3887457-3887825 [Brenneria izadpanahii]
MDEYTPKHYDIAQLKFLCEYLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPDEGELSQRVEKYL
DDTYVLFSNYGINDAELRGWKKSKERLFGMFSEGDICTPAKT

Nucleotide

• Length: 369 bp

>AT153342 NZ_CP066851:3887407-3887697 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A1X3RNQ0