Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3831032..3831651 Replicon chromosome
Accession NZ_CP050845
Organism Klebsiella pneumoniae strain Bckp206

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HC704_RS19200 Protein ID WP_002892050.1
Coordinates 3831433..3831651 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HC704_RS19195 Protein ID WP_002892066.1
Coordinates 3831032..3831406 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC704_RS19185 3826184..3827377 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HC704_RS19190 3827400..3830546 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HC704_RS19195 3831032..3831406 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HC704_RS19200 3831433..3831651 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HC704_RS19205 3831810..3832376 + 567 WP_002892030.1 maltose O-acetyltransferase -
HC704_RS19210 3832348..3832488 - 141 WP_004147370.1 hypothetical protein -
HC704_RS19215 3832509..3832979 + 471 WP_031588394.1 YlaC family protein -
HC704_RS19220 3832954..3834405 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HC704_RS19225 3834506..3835204 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HC704_RS19230 3835201..3835341 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HC704_RS19235 3835341..3835604 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153332 WP_002892050.1 NZ_CP050845:3831433-3831651 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T153332 NZ_CP066845:99231-99647 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT153332 WP_002892066.1 NZ_CP050845:3831032-3831406 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT153332 NZ_CP066845:99004-99234 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References