Detailed information of TA system TA153331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2506870..2508458
• Replicon: chromosome
• Accession: NZ_CP050845
• Organism: Klebsiella pneumoniae strain Bckp206

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HC704_RS12595
• Protein ID: WP_023280065.1
• Coordinates: 2506870..2508192 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HC704_RS12600
• Protein ID: WP_002904790.1
• Coordinates: 2508192..2508458 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC704_RS12580	2501926..2504427	+	2502	WP_023280067.1	fimbrial biogenesis outer membrane usher protein	-
HC704_RS12585	2504415..2505419	+	1005	Protein_2410	type 1 fimbrial protein	-
HC704_RS12590	2505561..2506853	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HC704_RS12595	2506870..2508192	-	1323	WP_023280065.1	type II toxin-antitoxin system HipA family toxin	Toxin
HC704_RS12600	2508192..2508458	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HC704_RS12605	2508723..2509049	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
HC704_RS12610	2509046..2509546	-	501	WP_023280064.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HC704_RS12615	2509524..2510903	-	1380	WP_031589628.1	purine permease	-
HC704_RS12620	2511249..2512403	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HC704_RS12625	2512384..2513307	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49137.45 Da
• Isoelectric Point: 7.5357

>T153331 WP_023280065.1 NZ_CP050845:c2508192-2506870 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPIDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T153331 NZ_CP066845:c94819-94514 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT153331 WP_002904790.1 NZ_CP050845:c2508458-2508192 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT153331 NZ_CP066845:c95039-94821 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8