Detailed information of TA system TA153314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4773207..4773723
• Replicon: chromosome
• Accession: NZ_CP050843
• Organism: Klebsiella pneumoniae strain Bckp186

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC697_RS23825
• Protein ID: WP_040216106.1
• Coordinates: 4773207..4773491 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: HC697_RS23830
• Protein ID: WP_002886901.1
• Coordinates: 4773481..4773723 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC697_RS23800	4768689..4768997	-	309	WP_020079792.1	PTS sugar transporter subunit IIB	-
HC697_RS23805	4769082..4769255	+	174	WP_032412860.1	hypothetical protein	-
HC697_RS23810	4769258..4770001	+	744	WP_050886150.1	MurR/RpiR family transcriptional regulator	-
HC697_RS23815	4770359..4772497	+	2139	WP_167830358.1	anaerobic ribonucleoside-triphosphate reductase	-
HC697_RS23820	4772739..4773203	+	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HC697_RS23825	4773207..4773491	-	285	WP_040216106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC697_RS23830	4773481..4773723	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HC697_RS23835	4773801..4775711	-	1911	WP_167830359.1	BglG family transcription antiterminator	-
HC697_RS23840	4775734..4776888	-	1155	WP_167830360.1	lactonase family protein	-
HC697_RS23845	4776955..4777695	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.94 Da
• Isoelectric Point: 10.4962

>T153314 WP_040216106.1 NZ_CP050843:c4773491-4773207 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T153314 NZ_CP066844:1042326-1042661 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT153314 WP_002886901.1 NZ_CP050843:c4773723-4773481 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT153314 NZ_CP066844:1042078-1042326 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCAGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGAAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0