Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835725..836382 Replicon chromosome
Accession NZ_CP050843
Organism Klebsiella pneumoniae strain Bckp186

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HC697_RS04285 Protein ID WP_002916310.1
Coordinates 835972..836382 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HC697_RS04280 Protein ID WP_002916312.1
Coordinates 835725..835991 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC697_RS04255 830881..832314 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HC697_RS04260 832433..833161 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HC697_RS04265 833211..833522 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HC697_RS04270 833686..834345 + 660 WP_002916317.1 hemolysin III family protein -
HC697_RS04275 834496..835479 - 984 WP_038991498.1 tRNA-modifying protein YgfZ -
HC697_RS04280 835725..835991 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HC697_RS04285 835972..836382 + 411 WP_002916310.1 protein YgfX Toxin
HC697_RS04290 836389..836910 - 522 WP_004144730.1 flavodoxin FldB -
HC697_RS04295 837011..837907 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HC697_RS04300 837930..838643 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HC697_RS04305 838649..840382 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T153302 WP_002916310.1 NZ_CP050843:835972-836382 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T153302 NZ_CP066839:c4208175-4207888 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT153302 WP_002916312.1 NZ_CP050843:835725-835991 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT153302 NZ_CP066839:c4207901-4207599 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References