Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 69230..69966 Replicon plasmid pBckp101-1
Accession NZ_CP050841
Organism Klebsiella pneumoniae strain Bckp101

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag HC692_RS26650 Protein ID WP_003026803.1
Coordinates 69484..69966 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag HC692_RS26645 Protein ID WP_003026799.1
Coordinates 69230..69496 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC692_RS26635 65212..65790 - 579 WP_004206571.1 recombinase family protein -
HC692_RS26640 65949..68933 + 2985 Protein_67 Tn3 family transposase -
HC692_RS26645 69230..69496 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
HC692_RS26650 69484..69966 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
HC692_RS26655 70178..71524 + 1347 WP_077251107.1 ISNCY family transposase -
HC692_RS26660 71684..72388 + 705 WP_040167821.1 toll/interleukin-1 receptor domain-containing protein -
HC692_RS26665 72723..72980 - 258 WP_023292103.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97812 97812
- inside IScluster/Tn - - 65212..71524 6312


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T153298 WP_003026803.1 NZ_CP050841:69484-69966 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T153298 NZ_CP066839:2910115-2910222 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT153298 WP_003026799.1 NZ_CP050841:69230-69496 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT153298 NZ_CP066839:c2910068-2910002 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References