Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5249822..5250447 | Replicon | chromosome |
Accession | NZ_CP050840 | ||
Organism | Klebsiella pneumoniae strain Bckp101 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | HC692_RS25905 | Protein ID | WP_002882817.1 |
Coordinates | 5249822..5250205 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | HC692_RS25910 | Protein ID | WP_004150355.1 |
Coordinates | 5250205..5250447 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HC692_RS25890 | 5247188..5248090 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
HC692_RS25895 | 5248087..5248722 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
HC692_RS25900 | 5248719..5249648 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
HC692_RS25905 | 5249822..5250205 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HC692_RS25910 | 5250205..5250447 | - | 243 | WP_004150355.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
HC692_RS25915 | 5250652..5251569 | + | 918 | WP_020802762.1 | alpha/beta hydrolase | - |
HC692_RS25920 | 5251583..5252524 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
HC692_RS25925 | 5252569..5253006 | - | 438 | WP_002882809.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
HC692_RS25930 | 5253003..5253863 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
HC692_RS25935 | 5253857..5254456 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T153297 WP_002882817.1 NZ_CP050840:c5250205-5249822 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
>T153297 NZ_CP066839:2909580-2909687 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT153297 WP_004150355.1 NZ_CP050840:c5250447-5250205 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT153297 NZ_CP066839:c2909533-2909467 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |