Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4774697..4775213 Replicon chromosome
Accession NZ_CP050840
Organism Klebsiella pneumoniae strain Bckp101

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HC692_RS23610 Protein ID WP_004178374.1
Coordinates 4774697..4774981 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HC692_RS23615 Protein ID WP_002886901.1
Coordinates 4774971..4775213 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC692_RS23585 4770181..4770489 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
HC692_RS23590 4770574..4770747 + 174 WP_032444549.1 hypothetical protein -
HC692_RS23595 4770750..4771493 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HC692_RS23600 4771850..4773988 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HC692_RS23605 4774229..4774693 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HC692_RS23610 4774697..4774981 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HC692_RS23615 4774971..4775213 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HC692_RS23620 4775291..4777201 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HC692_RS23625 4777224..4778378 - 1155 WP_004178372.1 lactonase family protein -
HC692_RS23630 4778445..4779185 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T153296 WP_004178374.1 NZ_CP050840:c4774981-4774697 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T153296 NZ_CP066839:c2701277-2701101 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT153296 WP_002886901.1 NZ_CP050840:c4775213-4774971 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT153296 NZ_CP066839:c2701055-2700639 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References