Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4044582..4045201 Replicon chromosome
Accession NZ_CP050840
Organism Klebsiella pneumoniae strain Bckp101

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HC692_RS20065 Protein ID WP_002892050.1
Coordinates 4044983..4045201 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HC692_RS20060 Protein ID WP_002892066.1
Coordinates 4044582..4044956 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HC692_RS20050 4039734..4040927 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HC692_RS20055 4040950..4044096 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HC692_RS20060 4044582..4044956 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HC692_RS20065 4044983..4045201 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HC692_RS20070 4045360..4045926 + 567 WP_002892030.1 maltose O-acetyltransferase -
HC692_RS20075 4045898..4046038 - 141 WP_004147370.1 hypothetical protein -
HC692_RS20080 4046059..4046529 + 471 WP_031588394.1 YlaC family protein -
HC692_RS20085 4046504..4047955 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HC692_RS20090 4048056..4048754 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HC692_RS20095 4048751..4048891 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HC692_RS20100 4048891..4049154 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T153293 WP_002892050.1 NZ_CP050840:4044983-4045201 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T153293 NZ_CP066839:1296827-1297162 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT153293 WP_002892066.1 NZ_CP050840:4044582-4044956 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT153293 NZ_CP066839:1296579-1296827 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References