Detailed information of TA system TA153263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2689677..2691265
• Replicon: chromosome
• Accession: NZ_CP050834
• Organism: Klebsiella pneumoniae strain Bckp021

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HC680_RS13230
• Protein ID: WP_032436337.1
• Coordinates: 2689943..2691265 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HC680_RS13225
• Protein ID: WP_002904790.1
• Coordinates: 2689677..2689943 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC680_RS13200	2684706..2685629	+	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-
HC680_RS13205	2685610..2686764	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HC680_RS13210	2687110..2688489	+	1380	Protein_2541	purine permease	-
HC680_RS13215	2688467..2688967	+	501	WP_032436335.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HC680_RS13220	2688964..2689290	+	327	WP_032436336.1	hydroxyisourate hydrolase	-
HC680_RS13225	2689677..2689943	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HC680_RS13230	2689943..2691265	+	1323	WP_032436337.1	type II toxin-antitoxin system HipA family toxin	Toxin
HC680_RS13235	2691282..2692574	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HC680_RS13240	2692715..2693719	-	1005	WP_032436338.1	type 1 fimbrial protein	-
HC680_RS13245	2693707..2696208	-	2502	WP_032436339.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49106.39 Da
• Isoelectric Point: 7.5617

>T153263 WP_032436337.1 NZ_CP050834:2689943-2691265 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T153263 NZ_CP066833:3277364-3277687 [Proteus mirabilis]
ATGAGCTGGAAGATCGACTTTTACGATGGCGTTGAGGATCAGATCCTCGATATGCCACCCAAAATACAAGCTCGCATGAT
TAAGCTTTTAGAGCTGATGGAAAAGCATGGTGCAAACTTGGGGCCTCCTCATACTGAGTCTATGGGCGATGGGTTATTTG
AAATCCGCGCCAAAGCTCAAGAAGGTATTGGTAGAGGCTTATTTTGCTACTTAAAAGGGAAGCACATTTATGTGTTACAC
GCTTTTGTAAAAAAATCTCAAAAGACGCCCAAAAATGAGCTCAATCTTGCCAGAGATAGACAAAAAGAGGTTCAAAAATC
ATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT153263 WP_002904790.1 NZ_CP050834:2689677-2689943 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT153263 NZ_CP066833:3277684-3277962 [Proteus mirabilis]
ATGAGTCTGCAAAAACTGAAACAACGTGCTTTAGCCAATGCTGAAGTTAAGAATGAGTACGATAAGCTTGAGAGTGAGTT
CAGCTTTATTGACCAATTGCTTACCATGAGAACAAAGGCGGGGCTTACTCAAGAACAGGTTGCTGAAAGAATGCATACCC
AAAAAAGTAATGTCAGTCGTTTAGAAAAAGGTAATGCCAATCCAAGTTGGTCAACTCTTCTAAAGTATGCTCACGCATGT
GGCTTTGAACTAACACTCAAGCCACAAAAAATGAGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8