Detailed information of TA system TA153260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 729187..729703
• Replicon: chromosome
• Accession: NZ_CP050834
• Organism: Klebsiella pneumoniae strain Bckp021

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HC680_RS03480
• Protein ID: WP_023317444.1
• Coordinates: 729419..729703 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: HC680_RS03475
• Protein ID: WP_002886901.1
• Coordinates: 729187..729429 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC680_RS03460	725215..725955	+	741	WP_004186692.1	KDGP aldolase family protein	-
HC680_RS03465	726022..727176	+	1155	WP_002886900.1	lactonase family protein	-
HC680_RS03470	727199..729109	+	1911	WP_004152270.1	BglG family transcription antiterminator	-
HC680_RS03475	729187..729429	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HC680_RS03480	729419..729703	+	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HC680_RS03485	729707..730171	-	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HC680_RS03490	730501..732639	-	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
HC680_RS03495	732996..733739	-	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
HC680_RS03500	733742..733915	-	174	WP_032408826.1	hypothetical protein	-
HC680_RS03505	734000..734308	+	309	WP_012737232.1	PTS sugar transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T153260 WP_023317444.1 NZ_CP050834:729419-729703 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T153260 NZ_CP066833:1725381-1725905 [Proteus mirabilis]
ATGACAATACCAAATTGGCACGAAGAAGCGATCAGTAAAAAACATAATAGAAATGGATTTAATTGTGGCGATGCAGTACT
AAACCAATTTCTGTATCGCCATGCAAGACAAAATCATGAGAATGGTAGTGCGAAAACATATTTAGCTATCAATAATAGTA
ATAATATTATATTAGGTTATTACAGCTTATGTCCTGCTTCTATTGAGTTCGAAAGAACGCCCGAATTGATCAAACATGGC
TTAGCGCGTCATGATATCCCTGTTTTTAAACTTGCACGACTAGCTACGGATCTATCCGTTCAAGGAAAAGGTTTGGGTGG
GCAATTATTGCTTGCAGCAGGAAGGCGTTGTCTTTCCGTTGCTAGTGAATTGGGAGGCGTTGCTTTACTTATAGATGCTA
AAAATGAACGAGTCGCTAATTGGTATATTAGCTACGGGGCAATACCATTATTAGATACCCCTCTTTCTTTATTAATTTCC
TTTAAAACCATTTATACTGCACTTTCAATGGCAAATAAAATATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT153260 WP_002886901.1 NZ_CP050834:729187-729429 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT153260 NZ_CP066833:1725106-1725384 [Proteus mirabilis]
ATGGCTCAAGCACTAGTAGAAAACAGTGAACGAGTGTCAATTCGTATCACTACAGAAGATAAATCACTGCTGGTTCGTGC
TGCTAGTTTGGAAAATACAAACTTAACAGAGTTTGTACTTCGTAATATTGTACCTGTAGCTCGGCAAGTTATTGAAAATA
ATGAGCGTTTAAAATTATCAGAAAAAGACACATTACGTGTTATGGAACTTTTAGATAATCCACCAAAGCCTAATGCTAAA
CTACTTGCAGCGGCTTTTGCTCTACCGGACAATGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0