Detailed information of TA system TA153255

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 4471389..4471912
• Replicon: chromosome
• Accession: NZ_CP050831
• Organism: Bacteroides sp. CBA7301

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BacF7301_RS16485
• Protein ID: WP_167964482.1
• Coordinates: 4471389..4471661 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A6H0KR20
• Locus tag: BacF7301_RS16490
• Protein ID: WP_022139717.1
• Coordinates: 4471652..4471912 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BacF7301_RS16475	4466761..4469508	+	2748	WP_167964478.1	SusC/RagA family TonB-linked outer membrane protein	-
BacF7301_RS16480	4469523..4471307	+	1785	WP_167964480.1	RagB/SusD family nutrient uptake outer membrane protein	-
BacF7301_RS16485	4471389..4471661	-	273	WP_167964482.1	Txe/YoeB family addiction module toxin	Toxin
BacF7301_RS16490	4471652..4471912	-	261	WP_022139717.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BacF7301_RS16495	4472018..4473157	-	1140	WP_167964484.1	DNA alkylation repair protein	-
BacF7301_RS16500	4473281..4474471	-	1191	WP_167964486.1	molecular chaperone DnaJ	-
BacF7301_RS16505	4474498..4475082	-	585	WP_167964488.1	nucleotide exchange factor GrpE	-
BacF7301_RS16510	4475279..4476898	+	1620	WP_167964490.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10856.67 Da
• Isoelectric Point: 9.7533

>T153255 WP_167964482.1 NZ_CP050831:c4471661-4471389 [Bacteroides sp. CBA7301]
MEIKLLEQARIDLEYWKKTGNKVIMNKITALLRDISEHPYTGIGKPEPLKYELAGKWSRRINSEHRIIYSVHEDTIEIYV
FSMRYHYMKK

Nucleotide

• Length: 273 bp

>T153255 NZ_CP066815:15418-15705 [Aeromonas caviae]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9780.00 Da
• Isoelectric Point: 4.4805

>AT153255 WP_022139717.1 NZ_CP050831:c4471912-4471652 [Bacteroides sp. CBA7301]
MRTTNYSELRNNLKSYLDAVINDSEPLIVHRSGNESVVVISLEEYNSIKETEYIMKSPAMMDIIRKGDDEIKNGGGTSVD
IENLWK

Nucleotide

• Length: 261 bp

>AT153255 NZ_CP066815:15692-16006 [Aeromonas caviae]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A6H0KR20