Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 20238..21148 | Replicon | plasmid pBckp067 |
| Accession | NZ_CP050830 | ||
| Organism | Klebsiella pneumoniae strain Bckp067 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | HC709_RS26585 | Protein ID | WP_032413375.1 |
| Coordinates | 20678..21148 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A7H4PRG4 |
| Locus tag | HC709_RS26580 | Protein ID | WP_032413443.1 |
| Coordinates | 20238..20681 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HC709_RS26545 | 16072..17070 | + | 999 | WP_032413381.1 | N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB | - |
| HC709_RS26550 | 17117..18295 | + | 1179 | WP_032413379.1 | cystathionine gamma-synthase family protein | - |
| HC709_RS26555 | 18432..18779 | + | 348 | WP_032413377.1 | hypothetical protein | - |
| HC709_RS26560 | 18837..18962 | + | 126 | Protein_19 | transposase | - |
| HC709_RS26565 | 19096..19320 | - | 225 | Protein_20 | transposase | - |
| HC709_RS26570 | 19340..19525 | + | 186 | WP_071571073.1 | DUF2188 domain-containing protein | - |
| HC709_RS26575 | 19626..20138 | + | 513 | Protein_22 | DUF4113 domain-containing protein | - |
| HC709_RS26580 | 20238..20681 | + | 444 | WP_032413443.1 | DUF2384 domain-containing protein | Antitoxin |
| HC709_RS26585 | 20678..21148 | + | 471 | WP_032413375.1 | RES family NAD+ phosphorylase | Toxin |
| HC709_RS26590 | 21258..21518 | - | 261 | WP_017901409.1 | hypothetical protein | - |
| HC709_RS26595 | 22090..22467 | - | 378 | Protein_26 | transposase | - |
| HC709_RS26600 | 22541..22734 | + | 194 | Protein_27 | transposase | - |
| HC709_RS26605 | 22857..23824 | + | 968 | Protein_28 | IS5 family transposase | - |
| HC709_RS26610 | 24078..24308 | + | 231 | WP_001261276.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| HC709_RS26615 | 24305..24721 | + | 417 | WP_045337409.1 | type II toxin-antitoxin system VapC family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..222783 | 222783 | |
| - | inside | IScluster/Tn | - | - | 18807..26328 | 7521 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17547.79 Da Isoelectric Point: 4.5152
>T153252 WP_032413375.1 NZ_CP050830:20678-21148 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIAFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIAFRFDSRLKPDRK
Download Length: 471 bp
>T153252 NZ_CP066812:2272404-2272982 [Mycobacterium avium subsp. paratuberculosis]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16508.82 Da Isoelectric Point: 10.3013
>AT153252 WP_032413443.1 NZ_CP050830:20238-20681 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT153252 NZ_CP066812:2271984-2272373 [Mycobacterium avium subsp. paratuberculosis]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAAATCACCGCCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAAATCACCGCCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|